Therapy of bronchial asthma in children: age-related aspects

Геппе, Н.А.; Анатольевна, Геппе Наталья; Кондюрина, Е. Г.; Геннадьевна, Кондюрина Елена; Reviakina, Vera; Revyakina, V A; Malakhov, A.B.; Борисович, Малахов Александр; Колосова, Н.Г.; Георгиевна, Колосова Наталья

doi:10.26442/26586630.2021.2.200928

Cited by 5 publications

(5 citation statements)

References 26 publications

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“…Однако практически ни один из этих показателей в отдельности (включая уровень IgE) не может служить достаточно достоверным дифференциальнодиагностическим критерием обструктивного бронхита и БА [1, 9,14,23]. В то же время очень важной задачей является своевременное назначение ребёнку базисной противовоспалительной терапии, что позволяет уменьшить риск ремоделирования респираторного тракта [1,2,7,24].…”

Section: A R T I C L E I N P R E S Sunclassified

“…Такие пациенты формируют группу риска по БА и требуют тщательного наблюдения для первичной профилактики заболевания. В этом случае педиатр может назначить противовоспалительную терапию ингаляционными глюкокортикоидами в низких дозах или блокаторами лейкотриеновых рецепторов на 4-8 нед с обязательным мониторированием состояния пациента на фоне лечения через 1 и 3 мес [1,11,24]. Все авторы подтверждают соответствие своего авторства международным критериям ICMJE (все авторы внесли существенный вклад в разработку концепции, проведение исследования и подготовку статьи, прочли и одобрили финальную версию перед публикацией).…”

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Development and implementation in outpatient practice of an electronic computer program “Diagnostics of bronchial asthma in children”

Самигуллина

2023

Russian Journal of Allergy

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Background. Currently, the criteria for the differential diagnosis of bronchial asthma and a number of respiratory diseases in children, accompanied by bronchial obstruction syndrome, remain insufficiently effective. At the same time, timely administration of anti-inflammatory therapy is important.Aim: Development and introduction into the practice of outpatient medical organizations of a computer program for the timely diagnosis of asthma in children and the appointment of basic therapy.Materials and methods. A comparative comprehensive analysis of risk factors for the formation of the disease was carried out in 170 children with bronchial asthma and 170 clinically healthy children who had episodes of bronchial obstruction at an early age. The program was tested in the observation of 72 children with episodes of bronchial obstruction.Three years after the introduction of the program into practice, an analysis was made of the diagnosis of bronchial asthma in 92 children.Results. 62 most significant signs (predictors of the disease) were established, which formed the basis of the developed computer program "Diagnostics of bronchial asthma in children". Approbation of the program in clinical conditions showed a high consistency of the result with the conclusion of an allergist-immunologist. Statistical analysis showed that the sensitivity of the method was 88.2%, the specificity was 94.1% (p0.05). The program was introduced into the practice of outpatient medical organizations.Three years after the introduction of the program into the practice of outpatient institutions, the number of patients diagnosed with asthma during the year increased by 3 times.Conclusion. The data obtained determine the possibility of using the proposed computer program as a tool for the timely diagnosis of BA in children.

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Development and implementation in outpatient practice of an electronic computer program “Diagnostics of bronchial asthma in children”

Самигуллина

2023

Russian Journal of Allergy

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“…Согласно современным рекомендациям, при легкой интермиттирующей и персистирующей БА альтернативой ИГКС являются АЛТР (монтелукаст) [2,4,9]. Это первая медиатор-специфическая терапия БА.…”

Section: роль антагониста лейкотриеновых рецепторовunclassified

Approaches to the treatment of bronchial asthma in children: leukotriene receptor antagonists

Kolosova,

Denisova

2023

Medicinskij sovet

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Asthma is a common heterogeneous disease, which often starts at a young age and has a reversible airway obstruction as its hallmark. Phenotypic differences in children with asthma may influence concomitant diseases and treatment choices. Despite the availability of effective drugs, asthma is poorly controlled in many children, which gives doctors the power to increasingly customize therapy from a personalized medicine perspective. The Global Initiative for Asthma (GINA) 2023 preserves and develops the agebased approach to diagnosis verification and therapy choice, which is supported in the All-Russia national program: Bronchial Asthma in Children and in the national clinical guidelines on bronchial asthma. Three age groups of patients were identified: zero to five years, six to eleven years and 12 years and older. Leukotriene receptor antagonists (in particular, montelukast) are often used in paediatric practice in children with asthma. The current guidelines show that leukotriene receptor antagonists (montelukast) are an alternative to inhaled glucocorticoids in mild, intermittent and persistent asthma. This is the first mediator-specific therapy for bronchial asthma. The best strategy in prescribing this group of drugs is to assess the severity of asthma, age and presence of concomitant diseases in children. The article uses clinical examples to discuss approaches to the asthma treatment with montelukast. The lack of asthma control tools results in high morbidity, mortality and costs of treatment, which justifies the search for new therapeutic options to improve control and reduce the risk of future exacerbations.

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“…Most researchers associate to a large extent with environmental pollution (atmospheric air, water, soil with chemical compounds). In Uzbekistan, studies have not been conducted to identify the prevalence of pneumonia and other bronchopulmonary pathologies, on risk factors and the impact of air pollution on an increase in the incidence of the disease among children living in rural and industrial regions [3,[4][5][6][7][8][9][10][11][12][13]. The main sources of indoor air pollution, in addition to outdoor air and new building materials, are tobacco smoking, the use of gas stoves for cooking and room heating, and gas water heaters.…”

Section: Introductionmentioning

confidence: 99%

“…One of the urgent scientific problems is the formation of mechanisms of immune and molecular genetic development of community-acquired pneumonia in young children, the identification of prognostic risk factors of the disease, the improvement of diagnostic criteria through modern innovative clinical diagnostic research methods, the development of effective methods of treatment and rehabilitation of the disease. Pneumonia of viral-bacterial etiology also requires study [10,[13][14][15][16][17][18][19][20][21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

The importance of environmental factors in the development of pneumonia in children

Karimjanov

Faizieva

2023

E3S Web of Conf.

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This article is devoted to modern innovative diagnostics, immunological tests for community-acquired pneumonia in young children. The main points for improving the diagnosis and differential diagnosis of pneumonia in children is the timely detection of a sick child with complicated course of the disease. According to the authors of the article, the content of cytokines IL 1 and IL4, interferons in the blood serum of sick children with community-acquired pneumonia depends on the period of the disease and the severity of the pathological process.

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Therapy of bronchial asthma in children: age-related aspects

Cited by 5 publications

References 26 publications

Development and implementation in outpatient practice of an electronic computer program “Diagnostics of bronchial asthma in children”

Development and implementation in outpatient practice of an electronic computer program “Diagnostics of bronchial asthma in children”

Approaches to the treatment of bronchial asthma in children: leukotriene receptor antagonists

The importance of environmental factors in the development of pneumonia in children

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