Heliogeophysical situation during prenatal development of humans is essential for blood rheology, hemostasis, and spectral and frequency parameters of the blood. The relationship between these parameters and natural physical factors is determined by the intensity of solar activity and geomagnetic induction during postnatal ontogeny. Analysis of changes in the functional relationship between hematological values and heliogeophysical factors under conditions of simulated hypogeomagnetic space included evaluation of possible consequences of distortions of the heliobiospheric relationships in large cities, particularly pronounced for cardiovascular patients.
Background. Hypertension (HTN) is often combined with other diseases, that significantly complicate its course, worsen the prognosis, interfere with the therapeutic and preventive measures. Therefore, assessing the development and structure of polymorbidity (PM) in hypertension is a relevant issue. Objective. To study the structure and degree of PM in hypertensive patients depending on age and gender. Design and methods. We conducted an analysis of 20 560 case histories of patients with HTN and without HTN (men and women), inhabitants of West Siberia-Novosibirsk region, who underwent examination and treatment at the clinic of the Federal Research Center of Fundamental and Translational Medicine in Novosibirsk. All identified diagnoses (nosological forms and classes according to the International Classification of Diseases of the 10th revision, ICD‑10) were considered. Transnosological PM was assessed by the average number of nosologies corresponding to the three-digit ICD‑10 rubric. Results. An increase in the PM index by 16,8 % was found in HTN patients compared to patients without HTN. Among HTN patients, there was an increase in the incidence of comorbid diseases of the circulatory system (in the 16–39 age group in men — by 46 %, in women — by 42,8 %), the endocrine system, eating disorders and metabolism (in the age group 16–39 years for men — by 19,3 %, for women — by 45,2 %), the musculoskeletal system, urinary system (for men) and neoplasms (for women) compared with patients without HTN. Conclusions. We found a high rate of transnosological PM in HTN patients was found and defined its structure.
Aim. To study the associations of the frequency and values of parameters of the main risk factors (RF) of cardiovascular diseases (CVD) and the degree of transnosological polymorbidity (PM) in patients with nonalcoholic fatty liver disease (NAFLD).Material and methods. The analysis of 3667 medical records (men, women) treated in the clinic of Research Institute of Experimental and Clinical Medicine (Novosibirsk) was carried out. Index of polymorbidity was evaluated by the number of nosological forms in accordance with the International Classification of Diseases, 10th revision (ICD-10). The following risk factors were assessed according to clinical and laboratory tests: arterial hypertension, dyslipidemia, hyperglycemia, obesity.Results. Both among men and women with increasing index of PM there was identified growth of the parameters that determine the main RF: systolic BP, diastolic BP, obesity (both in men and women), atherogenicity index (in women), glucose concentration in the blood serum (in women). Frequency of AH occurrence in persons with a high degree of PM among men was 49%, and among women — 69% higher, compared with persons with a low degree of PM. Among men, there was an increase in the incidence of AH (by 9%) and obesity (by 9%) in individuals with a high degree of PM, compared with individuals with an average degree of PM. Among women, there was an increase in the incidence of AH (by 15%), obesity (by 9%), hyperglycemia (by 11%) in persons with a high degree of PM, compared with individuals with an average degree of PM.Conclusion. There was established the role of risk factors for cardiovascular diseases, arterial hypertension mainly, in the development of polymorbidity in patients with NAFLD. The findings indicate the need for personified prevention and treatment of such patients with mandatory identification and correction of modifiable CVD RF.
The directionality of the proposed rehabilitation complex towards the common pathogenetic components of the development and progression of COPD and hypertension, as well as the high efficiency of the complex justify its appropriate inclusion in the combination treatment and rehabilitation of this category of patients.
Purpose. To study regional features of the association of frequency of occurrence and the magnitude of the indices of the main risk factors for chronic non-communicable diseases (RF CNCD) with the degree of transnosological polymorbidity (PM) in male residents of the Novosibirsk Region (NR) and Saha (Yakutia) Republic. Methods. The analysis of 10 187 medical records of patients with therapeutic profile (men), examined and treated in the clinic of the Federal Research Center for Fundamental and Translational Medicine, Novosibirsk was carried out. The index of transnosological polymorbidity was assessed by the number of nosological forms in accordance with the ICD-10. According to the clinical and laboratory examination, the following RF CNCD were assessed: high blood pressure, increased blood levels of total cholesterol, low-density lipoprotein cholesterol, triglycerides, glucose, uric acid, decreased blood level of low-density lipoprotein cholesterol, obesity. Results. Both among the residents of the NR and of the Yakutia, with an increase in the index of polymorbidity, there was an increase in the severity and frequency of occurrence of the studied RF CNCD. There was an increase in the frequency of occurrence in persons with high PM in comparison with those with a low degree of PM: arterial hypertension among residents of NR and of the Yakutia - by 2 times (p < 0.001), increase in total cholesterol in the blood among residents of the NR and of the Yakutia - by 1.2 times (p < 0.001, p = 0.003 respectively), obesity - for residents of the NR by 2.4 times, for residents of the Yakutia - by 1.7 times (p < 0.001), hyperglycemia - in residents of NR - by 2 times (p < 0.001), hyperuricemia - among residents of NR - by 1.5 times (p < 0.001). Conclusion. The role of some hemodynamic and metabolic risk factors of RF CNCD in the development of polymorbid pathology among residents of the regions of Siberia and the North has been established. The obtained data indicate the need to take into account the region of residence of such patients in the course of personalized prophylaxis with mandatory detection and correction of the modifiable RF CNCD.
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