Dynamics of blood values in experimental geomagnetic deprivation (in vitro) reflects biotropic effects of natural physical factors during early human ontogeny

Trofimov, A. V.; Севостьянова, Е. В.

doi:10.1007/s10517-008-0221-4

Cited by 4 publications

(2 citation statements)

References 3 publications

(3 reference statements)

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“…Previous experiments using short-term exposure to the HMF showed marked changes in oxidative stress levels 58 59 and sensitivity to environmental stimuli 11 17 , suggesting that the HMF may trigger a quick stress response. In our study, the changes in cell motility, cell morphology and WASL expression under the HMF condition also showed an acute response during the initial period of exposure (0–6 h) but followed with responses generally slowing and stabilizing during the final 12 hours of incubation (36–48 h).…”

Section: Discussionmentioning

confidence: 91%

Shielding of the Geomagnetic Field Alters Actin Assembly and Inhibits Cell Motility in Human Neuroblastoma Cells

Zhang

Wang

et al. 2016

Sci Rep

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Accumulating evidence has shown that absence of the geomagnetic field (GMF), the so-called hypomagnetic field (HMF) environment, alters the biological functions in seemingly non-magnetosensitive cells and organisms, which indicates that the GMF could be sensed by non-iron-rich and non-photo-sensing cells. The underlying mechanisms of the HMF effects on those cells are closely related to their GMF sensation but remain poorly understood so far. Previously, we found that the HMF represses expressions of genes associated with cell migration and cytoskeleton assembly in human neuroblastoma cells (SH-SY5Y cell line). Here, we measured the HMF-induced changes on cell morphology, adhesion, motility and actin cytoskeleton in SH-SY5Y cells. The HMF inhibited cell adhesion and migration accompanied with a reduction in cellular F-actin amount. Moreover, following exposure to the HMF, the number of cell processes was reduced and cells were smaller in size and more round in shape. Furthermore, disordered kinetics of actin assembly in vitro were observed during exposure to the HMF, as evidenced by the presence of granule and meshed products. These results indicate that elimination of the GMF affects assembly of the motility-related actin cytoskeleton, and suggest that F-actin is a target of HMF exposure and probably a mediator of GMF sensation.

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Section: Discussionmentioning

confidence: 91%

Shielding of the Geomagnetic Field Alters Actin Assembly and Inhibits Cell Motility in Human Neuroblastoma Cells

Zhang

Wang

et al. 2016

Sci Rep

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“…A significant age-related dynamics of associations of the physiological parameters with heliogeophysical factors in the prenatal ontogenesis of not only the persons surveyed but also of their parents was marked. It is shown the existence of genetically and epigenetically transferred from generation to generation "relay-race" of individual-generic sensitivity (steadiness) to the influence of various heliogeophysical factors, including galactic and solar flows of protons and electrons of different energies [4].…”

Section: Introductionmentioning

confidence: 99%

Heliogeophysical Aspects of Rheology: New Technologies and Horizons of Preventive Medicine

Trofimov¹,

Evgeniya²

2013

Rheology - New Concepts, Applications and Methods

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Non-Medicinal Helio-Magnetoprotective Remedies Against the Influence of Solar and Geomagnetic Disturbances on Human Physiological Parameters

Trofimov¹

2013

CMR

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The biotropic influence of ionospheric electrical currents (electrojets) and electromagnetic disturbances in the zone of the auroral oval on the electrical and cardiovascular homeostasis of healthy people was the topic of research. This was an investigation of non-medicinal helio-magnetoprotective remedies. "Helio-magnetoprotective" drinking water, certified and patented in Russia, has been developed for and tested in the circumpolar region (town Dixon) on inhabitants-volunteers with high level of helio-magnetosensitivity. This water after exposure to the repeatedly weakened magnetic field of the Earth ( device TRODR) substantially changes its structure, forming, on data of high effective chromatography, resistant nanocluster formations with marked biocatalytic properties which are enhanced with the use of the special informational holograms. Drinking water is treated using translucent holograms in this device is innovation technology. Helio-magnetoprotective water, according to our data, appears to be able to vary the degree of functional dependence of cardiovascular and other systems of both healthy and sick people on extreme impacts of heliogeophysical factors. Protective effect was assessed by changing in the vector of significant correlations: direct dependencies after drinking water became significantly reversed. Electrocardiographic parameters (R, PQ, QT), electrical conductivity in the cutaneous projections of acupuncture points, heart rate, and the blood pressure of the test subjects were registered three times: in the background conditions, 10 minutes after taking control water, and 10 minutes after receiving the same amount of helio-magnetoprotective water. The intensity of the polar electrojets and cosmic noise was determined by the methods of vertical sounding of the ionosphere and the riometer. The state of the polar magnetosphere was estimated according to the value of the Ak-index. It has been shown that the electrical and hemodynamic parameters of healthy people in the Far North are significantly altered during the periods of increased magnetic-ionospheric activity. Based on additional magnetic testing, the helio-magnetosensitivity of an organism increases during periods of increased level of cosmic noises as registered by riometers. Use of helio-magnetoprotective drinking water reduces the biotropic impacts of cosmophysical factors on human functional systems. The use of helio-magnetoprotective drinking water for prophylactic measures is effective against hello-dependent diseases, crisis states, and their life-threatening hemodynamic consequences for people living near the world's Polar Regions and an other places.

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Dynamics of blood values in experimental geomagnetic deprivation (in vitro) reflects biotropic effects of natural physical factors during early human ontogeny

Cited by 4 publications

References 3 publications

Shielding of the Geomagnetic Field Alters Actin Assembly and Inhibits Cell Motility in Human Neuroblastoma Cells

Shielding of the Geomagnetic Field Alters Actin Assembly and Inhibits Cell Motility in Human Neuroblastoma Cells

Heliogeophysical Aspects of Rheology: New Technologies and Horizons of Preventive Medicine

Non-Medicinal Helio-Magnetoprotective Remedies Against the Influence of Solar and Geomagnetic Disturbances on Human Physiological Parameters

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