There is considered modern classification of rhinitis and the accents in diagnostic and therapeutic approaches to patients with this disease are indicated, as well as the possibilities of using topical intranasal antihistamines in the treatment of allergic, vasomotor and medicamentous rhinitis.
The article analyzes international position papers on the allergen-specific immunotherapy mechanisms, discusses potential biomarkers for evaluation of ASIT efficacy, as well as the perspectives for ASIT enhancement.
In this review we describe FOXP3 (a specific marker of regulatory T-cells), nature of FOXP3 isoforms (with or without exon 2) expression and cooperation with other transcription factors under various immunopathological conditions and discuss the prospects for studying of FOXP3 isoforms expression in CD4+ T-cells in allergic diseases.
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