The genetic system in children with cerebral palsy was studied by the method of registration of chromosome aberrations and micronuclei in peripheral blood lymphocytes and erythrocytes. A high level of chromosome aberrations and micronuclei in the peripheral blood cells was revealed. A significant reduction of the integral antioxidant capacity of the blood and plasma was detected by coulombometric titration with electrogenerated bromine in patients with all forms of cerebral palsy. Aneugenic and antianeugenic effects of glutamate were studied in experiments on mice. Biphasic effect of glutamate was revealed: it exhibited aneugenic effect in high doses and antianeugenic in low doses. Impairment of the genome stability in children with cerebral palsy is believed to be caused by increased generation of endomutagens under conditions of disease and reduction of the genome antimutagenic defense system.
Aim. To study the relationship between the clinical and neurosonographic indicators of the hypertensive syndrome and blood hemoglobin level in infants with perinatal disorders of the central nervous system. Methods. A total of 58 children with a diagnosis of «Perinatal hypoxic-ischemic brain damage in the form of hypertensive syndrome» were examined at the age of 12 months and younger. Clinical, neurological examination, neuroimaging, laboratory tests and statistical analysis were performed. Results. The majority of infants who had suffered a hypoxia during labor and had clinical and neurosonographic signs of intracranial hypertension also had different stages of blood hemoglobin level decrease. Comparing the neurosonography data and hemoglobin levels, it was found that children with anemia dominated among children with primary accumulation of cerebrospinal fluid in the interhemispheric fissure. Neurosonography revealed interhemispheric fissure widening in 30 (51.7%) of infants, ventricular system widening - in 28 (48.3%) of infants. The anemia rate was high in infants with interhemispheric fissure widening - in 19 (63.3%) out of 30 infants. Anemia was more frequent in the full-term infants with interhemispheric fissure widening - 4 (87.5%) out of 16 infants, whereas prematurely born infants with interhemispheric fissure widening had relevantly higher rate of normal hemoglobin level - 9 (64.3%) out of 14 infants. In 28 infants with ventriculomegaly 23 (82.1%) had widened anterior horns of the lateral ventricles. In 14 (59.3%) of infants with dilatation of the anterior horns of the lateral ventricles hemoglobin level was within the age-appropriate normal limits. Conclusion. Reduced hemoglobin level aggravates the symptoms of intracranial hypertension, and the continuing anemia leads to tissue edema, which leads to a rapid increase of degenerative changes in the brain, causing mental and physical retardation.
ГОУ ВПО «Казанский государственный медицинский университет», кафедра неврологии, нейрохирургии и медицинской генетики, кафедра клинической иммунологии с аллергологией, г. Казань Резюме.Рассмотрены нейроиммунологические подходы в понимании патогенеза детского церебрального паралича. Показано участие факторов иммунной системы и цитокиновой регуляторной сети (фактора некроза опухолей альфа, интерлейкинов) в развитии патологических процессов у больных с перивентрикулярной лейкомаляцией с исходом в ДЦП. Проанализирована избирательная цитотоксическая активность TNFα при длительном хроническом процессе. Представлена роль иммунопатологических процессов в развитии цитогенетических перестроек в клетках периферической крови. Ключевые слова: детский церебральный паралич, перивентрикулярная лейкомаляция, нейроиммунологические механизмы, фактор некроза опухоли, цитокины.
Проблема изучения перинатальной патологии нервной системы у детей раннего возраста остается в настоящее время наиболее актуальной. Среди детей, впервые признанных инвалидами, 57% составляют больные детским церебральным
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.