years after its beginning. Allergic anaphylactoid reactions at the 10th and 14th infusions caused the drug withdrawal in 2 children (14,3%). In one year the treatment was completed in 9 patients (64,3%). The positive effect (improvement on at least 30% according to the ACRpedi criteria) in 2 weeks after the 1st infusion was registered in the majority of the patients (12 of 14 children, 85,7%). In 6 months of the treatment the improvement was achieved in all patients who continued to receive the drug. By the end of the 1st year of the treatment secondary inefficiency was found in 2 ofОснову патогенетического лечения ЮИА составля-ет назначение иммуносупрессивных препаратов, среди которых препаратом первого ряда является метотрек-сат. На сегодняшний день метотрексат рассматривают как «золотой стандарт» в лечении ревматоидного артрита и ЮИА, что обусловлено достаточно высокой его эффек-тивностью и безопасностью при длительном применении, низкой стоимостью, несложным мониторингом, широкими возможностями комбинации с другими противоревмати-ческими лекарственными средствами [3,4]. В то же время анализ данных литературы показал, что эффективность метотрексата по результатам большинства исследований составляет лишь 61-75% [5]. Это побудило исследователей к разработке лекарственных препаратов, избирательно

Juvenile arthritis (JA) is a disease of unknown etiology that begins before the age of 16 years and lasts for at least 6 weeks. The main objective of most existing international registers of children with JA is assessment various aspects of the efficacy and safety of biologics in comparison with methotrexate. The results of the analysis of the effectiveness of registers as a tool for long-term monitoring of the disease and medical care for children with JA are not presented in the available literature. The aim of the study is to develop methodological approaches to maintaining the Register of children with JA and algorithms of actions of medical personnel on the basis of the experience of the Republican Children's Clinical Hospital (Ufa). This work is a retro- and prospective observational study. The Register included children under the age of 18 years with an established diagnosis of JA, who were admitted to the cardio-rheumatologic department of Republican Children's Clinical Hospital (Ufa). In this paper, we used the All-Russian register of children with JA, developed by «Aston Consulting» and «Norbit» (official partner of Microsoft) on the basis of the technological platform Microsoft Dynamics CRM 5.0. In total, the Register included information about 426 children with JA. The average age of children during the analysis of the register data was 10.9±4.3 years, and in the onset of the disease – 4.7±3.7 years. According to the results of the analysis, the tasks, areas of responsibility and scope of action for each subject of medical care (rheumatologist of rheumatology hospital and office, head of department, chief freelance specialist of the Ministry of Health) and the corresponding tools of the Register were determined. A clear algorithm of actions of specialists depending on the task will optimize the work with the register of patients, reduce the time required to enter and receive information and, at the same time, provide the possibility of the most complete and effective use of the Register in optimizing medical care for children with JA.

No abstract

Background The quality of life is an integral parameter of the state of health that reflects peculiarities of the child’s physical, social, and psychological functioning. Objectives We carried out a study of psychological peculiarities and quality of life of 92 patients with juvenile idiopathic arthritis (32 boys and 60 girls) and 109 healthy children (45 boys and 64 girls) at the age of 7-17 years. Methods To evaluate psychological peculiarities of children’s personality, we used the children’s and teenagers’ variants of the R. Kettel test. The quality of life was also studied with aid of Pierce–Harris test composed of 126 questions. The test was represented by scales “Behavior”, “Intellectual and school status”, Physical appearance”, “Anxiety”, “Popularity”, “Happiness and satisfaction”, “Health”, “Psycho-social status”. The scale “Health” includes subscales “Health”, “Necessity in care”, “Physical development and mobility”, “Everyday life activity”, “Nutrition”, “Pain”. Results In children and teenagers with juvenile idiopathic arthritis there was revealed deterioration of the life quality with respect both of health and of their psycho-social status. The degree of the decrease of the life quality level depends not only on duration and activity of arthritis, functional insufficiency, “internal picture of disease”, but also on the child’s personality peculiarities. Children with such personality peculiarities as sociability, communicability, emotional stability, high self-control, social courage, which determine successful psycho-social adaptation, are characterized by the higher parameters of the majority of Pearce–Harris subscales and, accordingly, by the higher quality of life. Such personality peculiarities as anxiety, tension, the lack of motivations for changes and achievements, determine the lower life quality parameters. Besides, it is to be taken into account that these interconnections of parameters of the life quality can be due to the level of self-appraisal depending on psychological peculiarities of the child’s personality. Conclusions The quality of life of patients with juvenile idiopathic arthritis is determined as the subjective evaluation not only by peculiarities of the course of the disease, but also by the psychological peculiarities, which indicates necessity of the social and psychological support of such children. Disclosure of Interest None Declared