Fluorescent dyes absorbing and emitting in the visible and near-IR regions are promising for the development of fluorescent probes for labeling and bio-visualization of body cells. The ability to absorb and emit in the long-wavelength region increases the efficiency of recording the spectral signals of the probes due to the higher permeability of the skin layers. Compared to other fluorescent dyes, BODIPYs are attractive due to their excellent photophysical properties–narrow absorption and emission, intense fluorescence, simple signal modulation for the practical applications. As part of conjugates with biomolecules, BODIPY could act as a biomarker, but as therapeutic agent, which allows solving several problems at once-labeling or bioimaging and treatment based on the suppression of pathogenic microflora and cancer cells, which provides a huge potential for practical application of BODIPY conjugates in medicine. The review is devoted to the discussion of the recent, promising directions of BODIPY application in the field of conjugation with biomolecules. The first direction is associated with the development of BODIPY conjugates with drugs, including compounds of platinum, paclitaxel, chlorambucil, isoxazole, capsaicin, etc. The second direction is devoted to the labeling of vitamins, hormones, lipids, and other biomolecules to control the processes of their transport, localization in target cells, and metabolism. Within the framework of the third direction, the problem of obtaining functional optically active materials by conjugating BODIPY with other colored and fluorescent particles, in particular, phthalocyanines, is being solved.

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In complexes of Cu 2+ , Ni 2+ , Co 2+ , Zn 2+ , and Hg 2+ with 3,3`,5,5`-tetramethyl-4,4`-dibutyl-2,2`-dipyrrolylmethene, the d-metal ion exerts an auxochromic effect on the p system of the ligand, manifested in a bathochromic shift of the first absorption band in the spectrum of the complex, compared to the free ligand. Polarization of the chromophore p system in the complexes increases in the order Zn 2+ < Hg 2+ < Co 2+ < Ni 2+ < Cu 2+ . The Hg 2+ ion in the complex with dipyrrolylmethene participates in mercuration of benzene and chloroform; the reaction with chloroform is faster, with the rates of both reactions strongly depending on temperature.Development of studies in the chemistry of polypyrrole compounds is mainly stimulated by their unique biological effect as photoreceptors in the structures of some chromoproteins and intermediate substrates of porphyrin metabolism, and also by their wide use in preparative organic chemistry for synthesis of various manmade and natural porphyrins [1,2]. The efficiency of template synthesis of porphyrins from dipyrrolylmethenes on a metal ion matrix is largely determined by the chelating power of the dipyrrolyl ligand and by the physicochemical properties of the resulting chelates. Therefore, the search for new efficient procedures for template synthesis of porphyrins should be based on systematic data on the reactivity of linear polypyrrole compounds toward various metal ions and on physicochemical properties of the corresponding chelates. Such data are limited [23 4].

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