On SmSb single crystals synthesized from elements, the electrical resistance R and magnetization M were measured as functions of temperature and magnetic field. A large magnetoresistance is observed over the entire temperature range of 2–300 K, increasing significantly with decreasing temperature. The temperature dependence of the magnetization exhibits a singularity at the transition temperature to the antiferromagnetic state TN=2.3 K. At temperatures below 8 K, de Haas-van Alphen oscillations are observed in the M(H) dependences, the frequencies of which do not change upon the transition through TN. Linear extrapolation of the dependence of the Landau indices N on the reciprocal of the magnetic field induction 1/B to zero gives the value N=0.75 at T=2 K, which indicates the presence of the Berry phase and indicates a nontrivial band topology in the SmSb compound.