Etiology of respiratory virus infections among 1699 hospitalized patients (HP) was determined by PCR during the period of increased influenza activity in 2012 - 2013 season. The rate of accidence of influenza virus in dependence of gender, age, social and demographic factors and previous vaccination was analysed. Young children dominated in the age structure of HP, while the elderly were hospitalized very rarely. According to results obtained rate of influenza detection in HP was significantly higher among adults in comparison with children (63,5 and 30,7% of investigated patients, correspondingly). Respiratory syncytial virus and rhinoviruses were detected the most regularly (8.7 and 3.1%, correspondingly) in children, parainfluenza and adenoviruses were registered rarely (1.4 and 2.1%, correspondingly). Rate of detection of coronaviruses and bocavirus was low and varied in the range 0.3 - 0.6%. Indicated above ARI agents among hospitalized adults were detected rarely (0 - 1.5%) with exception of RSV which was detected among elderly (75 - 84 years) in 5.9% cases. No metapneumovirus cases were detected among HP in indicated period. Although males dominated (58%) among HP influenza cases, regardless of the type/subtype, were registered more frequently among girls in comparison with the boys of the same age groups. Influenza cases were registered more frequenly as well among smoking than in not smoking patients. Young children dominated in the age structure of HP, while the elderly were hospitalized very rarely.
Т. Н. Рыбалкина и др. Значение герпесвирусов в этиологии ряда инфекционных и соматических заболеваний детей T.M., Guseva N.A. The results of long-term study of herpesvirus infection in the Department of Infectious Diseases in children RNIMU. Detskie Infektsii=Children's infections. 2017, 16 (2): 5-12.
Coronaviruses can cause damage to various parts of the respiratory system, gastrointestinal tract, and other organs and systems.The aim of the study: to monitor the circulation of seasonal coronaviruses in hospitalized children in the pre-pandemic period.Materials and methods: real-time multiplex PCR was used to test samples of nasopharyngeal mucus from 2188 patients aged 1 monthto 17 years, hospitalized with acute respiratory infection in 2014—2018. The results are presented with the indication of the fractions (%) and the calculation of the 95% confidence interval according to Klopper-Pearson. The differences between the groups were evaluated using the Pearson χ2 test. The differences in the groups were considered statistically significant at the level of the criterion p< 0.05.Results: monitoring of the circulation of pathogens of acute respiratory viral infection (ARVI) during 5 epidemic seasons showed that the appearance of a new subtype of coronavirus in 2019 was preceded by a gradual displacement of influenza, RS-and bocavirus infections from the circulation due to a statistically significant increase in the proportion of seasonal coronaviruses from 3.6% in 2014—2015 to 10.8% in the prepandemic season 2018—2019 (p= 0.007). The circulation of seasonal coronaviruses had a distinct seasonality (november-april)with the peak of registration in february (28.4%) and march (36.7%). Seasonal coronaviruses were detected in 7.3% of hospitalized children with ARVI, with a predominance in the age groups under 2 years (58.2%) and 3—6 years (25.4%). Hospitalization was more often required for patients with lower respiratory tract lesions (58.2%), a fifth of which was pneumonia (21.8%). In most children, ARVI caused by coronaviruses occurred as a monoinfection (79.9%), combined infection with other pathogens was observed in 20.1% of cases with fluctuations from 18.2% to 28.6% in different epidemic seasons. Viral associations are most common in young children (85.2%).
1 ФГБОУ ВО «Санкт-Петербургский государственный педиатрический медицинский университет» Минздрава России, 2 Детская городская клиническая больница №5 имени Н.Ф. Филатова, Санкт-Петербург, РоссияПроведен клиническо-лабораторный анализ эффективности препарата ВИФЕРОН ® (суппозитории ректальные) у де-тей в возрасте от 1 мес. до 7 лет с острыми респираторными вирусными инфекциями (ОРВИ), сопровождающимися острым стенозирующим ларинготрахеитом (ОСЛТ), госпитализированных в ДГКБ №5 им. Филатова. Нами установле-но, что препарат ВИФЕРОН ® способствует статистически значимому сокращению продолжительности основных кли-нических проявлений заболевания, уменьшает выраженность и продолжительность клинических симптомов ОСЛТ, спо-собствует более быстрой элиминации вирусных антигенов. Ключевые слова: ВИФЕРОН ® суппозитории ректальные, острая респираторная вирусная инфекция (ОРВИ), дети, ост-рый стенозирующий ларинготрахеит (ОСЛТ)
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