Objective:
To study the relation between NT-proBNP and the condition of blood microcirculation in patients with controlled (CAH) and uncontrolled (UAH) course of hypertension.
Design and method:
A cross-sectional study included 27 patients with essential hypertension: group I (CAH) - 12 patients, group II (UAH) - 15. The average age was 59.6 ± 9.5 years, the average duration of hypertension was 13.6 ± 10.2 years, the function of the left ventricle was normal. The criteria for inclusion in group I were the constant use of correct therapy for hypertension, 24-hour BPM indicators within the reference values, the absence of hypertensive crises over the last year. All patients underwent measurement of NT-proBNP concentration, laser Doppler flowmetry of microvasculature vessels.
Results:
The concentration of NT-proBNP exceeded normal values in 4 patients (14.8%) in group I and in 1 patient (3.7%) in II, in group I this indicator was lower - 27.6 [21.4; 47.9] pg/ml than in group II - 45.15 [36.2; 102.0] pg/ml (p < 0.05).
According to the 24-BPM, the average daily (119.5 [112.0; 123.5]) and nocturnal (105.0 [99.5; 108.0]) SBP, as well as daily DBP (76 [64; 83]) in group I was lower than the similar indicators (136.0 [125.0; 164.0]), (122.5 [107.0; 144.0]) and (81 [75; 90]) in group II (p < 0.05). During the study of the microvasculature state, there was found an improvement in the microcirculation index (MI) in group I (30.55 [26.64; 34.37] compared to group II (22.19 [18.25; 26.05] (p < 0.05).
During the correlation analysis, the concentration of NT-proBNP in group I was correlated with the coefficient of variation of MI (r = 0.6; p < 0.05), the indicator of blood shunt (r = 0.59; p < 0.05), the maximum amplitude of the pulse factor regulating microcirculation (r = 0.71; p < 0.05), the contribution of the pulse factor to the total perfusion of tissues (r = 0.68; p < 0.05). In group II, the concentration of NT-proBNP had correlation with pulse BP (r = 0.54; p < 0.05).
Conclusions:
In patients with CAH there was detected a lower concentration of NT-proBNP along with lower values of SBP and DBP and better indicators of the state of blood microcirculation as compared with patients with UAH.
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