Multiple sclerosis is a chronic disabling disease of the central nervous system, afflicting mainly young people. The efforts of investigators around the world are aimed at creating highly effective disease-modifying therapies that have a favorable safety and tolerance profile. The review briefly lists the disease-modifying therapies currently registered in the Russian Federation. Information is provided on the international clinical trial phases II and III of disease-modifying therapies, international nonproprietary products and/or active substance molecules, intended mechanisms of action and indicators of their effectiveness and safety. The article describes disease-modifying therapies that have been approved by the FDA and that may be available for Russian neurologists in the near future for the treatment of multiple sclerosis. The treatment possibilities of drugs used in Russia for other indications than multiple sclerosis are discussed.
The aim of this study was to evaluate the state of blood flow in prostate in 59 men with chronic pelvic pain due to myofascial syndrome in the absence of clinical manifestations of chronic prostatitis and its dynamics against the background of the treatment. The results of the study revealed a reliable relationship between the severity of blood flow disorders in the prostate and the intensity of pain symptoms caused by myofascial syndrome. It was concluded that the hemodynamic disorders of the prostate caused by myofascial syndrome are important in the possible formation of clinical symptoms of chronic pelvic pain in men. (For citation: Krupin VN, Krupin AV, Belova AN, Nashivochnikova NA. The state of prostate hemodynamics in patients with myophascial pain syndrome. Urologicheskie vedomosti. 2017;7(4):39-43. doi: 10.17816/uroved7439-43).
This study provides an overview of the recent literature regarding the assessment methods of the functional state of the locomotor system in children with cerebral palsy. The objective methods of quantitative assessment of motor disorders in cerebral palsy are presented, including the measurement of stability, biomechanical assessment of walking, and video analysis of movements. The influence of the cognitive load on the ability to maintain the vertical posture in children with cerebral palsy as well as the changes in the stability of the vertical posture with closed eyes were observed. Changes in the walking parameters with an increase in the speed were also recorded in children with cerebral palsy. Methods that assess hand motion in children with cerebral palsy include tests involving the moving of objects, tests for speed assessment in joint movements, and video analysis of motions. The methods and tests for such an evaluation require to be valid and reliable, allowing an objective assessment of the severity of motor disorders in cerebral palsy.
A total of 127 patients (mean age 38.1 ± 7.8 years) with chronic bacterial prostatitis who had concomitant neurologic diseases were treated. The patients were divided into 3 groups: group 1 (n = 47) included those with pain of the upper lumbar spine and myofascial syndrome; group 2 (n= 41), those with disorders of general and peripheral autonomic tone with vascular disorders in the pelvis; and group 3 (n = 39), those with disorders of the joints of the pelvic girdle, ligaments, and muscles of the pelvic floor. Treatment was given for the specific neurologic and hemodynamic disorders identified. No antibiotic therapy was prescribed. Patients in group 1 were prescribed pathogenetic therapy, including manual and regional therapy (for effects on the sclerotome and myotome), as well as medical correction of hemodynamics, physiothe rapy, psychotherapy, and hyperbaric oxygenation. Group 2 received treatment aimed at correcting autonomic innervation, including medications and magnetic therapy. Patients in group 3 were prescribed specific therapy aimed at eliminating pain-provoking factors, medications, massage, physiotherapy, manual therapy, therapeutic exercises, and reflex therapy. Treatment was associated with a decrease in the severity of pain and improvement of pelvic hemodynamics in patients in all 3 groups. Thus, the results indicate the potential efficacy of pathogenetic therapy for patients with chronic bacterial prostatitis with concomitant neurologic pathology.
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