We have studied the level of autoantibodies to neurospecific proteins and neurotransmitters in patients with different forms of ischemic brain lesion. 49 patients with acute (ishemic stroke) and chronic cerebrovascular disease, 14 patients with ishemic heart disease and control group (35 healthy subjects) were investigated. The serum level of autoantibodies to glial fibrillary acidic protein (GFAP) and to dopamine (D) was determinated by ELISA. The content of autoantibodies to GFAP and D in patients with ischemic heart disease was practically identical. The patients with acute and chronic cerebrovas-cular diseases had the significally increased level of autoantibodies. The level of autoantibodies to GFAP in patients with acute vascular accidents (ischemic stroke) with favorable outcome was significantly higher than in patients with chronic cerebral ischemia. The obtained data allowed us to consider serum level of autoantibodies to GFAP as a marker of ischemic brain lesion, and to suppose further potential role of this autoantibodies in cerebrovascular disease progression.
Dorsalgia is one of the most common skeletal muscle syndromes. Dorsalgia often develops in patients of older age groups with polymorbidity that requires the appointment of a large number of medications. In these conditions, the choice of effective and safe therapy is a difficult problem. Discusses management of a patient suffering dorsalgia with comorbidities, the risks of complications of therapy, possible safety treatment, in particular, through the use of combination therapy.
Цель исследования: изучение влияния препарата Цитофлавин на частоту развития пневмонии в остром периоде ишемического инсульта (ИИ). Дизайн: мультицентровое проспективное сравнительное рандомизированное клиническое исследование. Материалы и методы. Наблюдали 101 больного с ИИ: 48 человек, помимо унифицированной терапии, получали Цитофлавин по 20 мл внутривенно (первая группа), у 53 человек применяли только унифицированную терапию (вторая группа). Оценивали частоту случаев развития пневмонии, функциональный исход ИИ, изменения лейкоцитарной формулы крови исходно, на 5-е и 9-е сутки наблюдения. Результаты. Клинико-лабораторные показатели обеих групп на момент госпитализации не различались. На 9-е сутки у пациентов первой группы в сравнении со второй группой отмечены менее выраженный очаговый неврологический дефицит (9,4 ± 1,9 против 12,8 ± 2,0 балла по Шкале оценки тяжести инсульта Национального института здоровья США, NIHSS) и бо ' льшая способность к самообслуживанию (78,3 ± 9,2 против 65,3 ± 5,3 по индексу Бартел), различия статистически значимы: p < 0,05. Впервые установлено, что у больных с ИИ, получающих Цитофлавин, реже развивается инсультассоциированная пневмония. Заключение. Полученные данные дают основания предполагать, что у Цитофлавина имеются свойства, позволяющие снизить риск развития пневмонии. Конкретные механизмы такого действия препарата требуют дальнейшего изучения. Ключевые слова: ишемический инсульт, атеротромботический инсульт, кардиоэмболический инсульт, пневмония, инсультассоциированная пневмония, Цитофлавин, лечение.
Introduction. Cerebral palsy is often combined with epilepsy and epileptiform electroencephalographic (EEG) activity. Currently, the question of how rehabilitation with cerebral palsy is dangerous in relation to the provocation of epileptic seizures is relevant. Objective: to study the effect of cerebral palsy rehabilitation on epilepsy in a standard rehabilitation center. Material and methods. We examined 80 children with various forms of cerebral palsy and epileptiform EEG activity. The patients were divided into two groups: children of Group 1 never had epileptic seizures, children of Group 2 had a history of epileptic seizures of more than 6 months ago. The follow-up was 12 months during which children underwent EEG before and after rehabilitation courses. Depending on the risks associated with provoking epileptic seizures, patients were prescribed rehabilitation procedures of various intensities: Vojta kinesiotherapy, massage, physiotherapeutic treatment in the form of transcranial micropolarization and paraffin therapy. Results. During the study, epileptic seizures developed in 5 patients (12.5%) from Group 1 and in 7 children (17.5%) from Group 2. In all cases, rare focal seizures were recorded (1–2 times a year). All patients with seizures during our study had a history of seizures under the age of 1 year. The onset of seizures was quickly stopped by the basic antiepileptic drugs in monotherapy. Epileptic seizures developed in children with moderate to severe cerebral palsy on GMFCS (Gross Motor Function Classification System) and a history of neonatal seizures. We attributed both of these to risk factors. In children with cerebral palsy and epilepsy in remission of 6 months or more, massage and Vojta therapy did not provoke epileptic seizures. The effect of epileptiform activity on the severity of motor status and on cognitive functions in cerebral palsy has not been established in our study. Conclusion. According to our data, rehabilitation measures do not have a significant impact on the risk of developing epilepsy.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.