The effects of tableting with KBr on the IR absorption spectra of molecular crystals were studied at room temperature. Study substances were mechanically activated mixtures of crystalline indomethacin and the excipient polyethylene glycol at ratios of 1:1 and 1:3. There was a marked widening of absorption bands in the range 2000 -500 cm -1 in the IR spectra of mechanically activated mixtures in tablets with KBr. These experimental results are assessed within the framework of possible interactions between study samples and the KBr matrix during tableting and storage as powered mixtures.
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