Synthesis of co-crystals of meloxicam with carboxylic acids by grinding

Equilibrium solubility measurement of ionizable drugs – consensus recommendations for improving data quality

“…Presence of cocrystals in the drug formulation is thus possible even when not anticipated. Cocrystals are often designed and produced on purpose, to increase the solubility, or the stability, or the tabletability of an active pharmaceutical ingredient (API) [30,92,96,[99][100][101][102][103][104]. However, when a cocrystal is dissolved, the initially high concentration of the API in solution can drop down with time, and sometimes this happens very fast.…”

Different effect of impact and shear mechanical treatment on mechanochemical cocrystallization of piroxicam and succinic acid

“…Joint mechanical treatment of a mixture of components in a mill or even in a hand mortar is more and more widely used for their synthesis [2]. Mechanochemical treatment is not just a preferred method but often the only possible [3].…”

Bis(paracetamol) pyridine – a new elusive paracetamol solvate: from modeling the phase diagram to successful single-crystal growth and structure–property relations

“…One of the main principles of designing a multi-component crystal is selecting coformers with complementary functional groups, molecular shapes and sizes 4,[14][15][16][17][18][19] . Crystallisation is traditionally used to purify compounds and to crystallise components selectively as 35 pure phases from multicomponent mixtures, be they solutions or melts 20-24 . Obtaining a multicomponent crystal remains a challenge even if all the requirements of molecular shape, size and complementarity of functional groups are fulfilled.…”

“…Crystallisation is traditionally used to purify compounds and to crystallise components selectively as 35 pure phases from multicomponent mixtures, be they solutions or melts 20-24 . In such cases, the multicomponent crystals can be obtained under non-equilibrium conditions only, such as rapid precipitation by anti-solvents, spray-drying, or by co-grinding 5,[29][30][31][32][33][34][35][36] . to co-crystallise several components in one solid phase, one needs to know the thermodynamics and kinetics of the process [25][26][27][28] .…”

“…Selecting the conditions for obtaining the paracetamol-pyridine25 solvate crystal suitable for single-crystal X-ray diffraction. (b) An illustration of the principle behind the selection of the optimal35 paracetamol concentration. Designations: Py -pyridine; P -paracetamol; Sparacetamol -pyridine solvate; l -liquor; s -solid phase.…”