It has been recently shown that manifestation of nonmonotonic concentration dependences of physicochemical properties of highly diluted solutions (10 -20 -10 -6 mol/L) of biologically active compounds (BACs) correlating with their bioeffects is caused by formation and rearrangement of nanoobjects (100-400 nm), referred to as nanoassociates (see review [1] and references therein). It has been revealed that nanoassociates are initiated by a solute under certain conditions, the most essential among which are the presence of external electromagnetic fields, the defi nite structure of the solute, and the procedure of prep aration of solutions. In highly diluted BAC solutions kept in a permalloy container, i.e., at reduced levels of external physical fields, nanoassociates are not formed and the properties of solutions correspond to the prop erties of the solvent, water. Based on analysis of data on self organization and physicochemical and biolog ical properties of highly diluted BAC solutions, we have suggested the method for predicting initiation of bioeffects [2]. Owing to nonmonotonic concentration dependences, these bioeffects are usually observed only in some dilution ranges corresponding to definite calculated concentrations.Numerous studies carried out in recent decades are evidence of the biological activity of highly diluted solutions in which the calculated concentration is much less than 10 -20 mol/L [3,4]. The detected bio logical activity of ultrahighly diluted solutions is prac tically used for drugs containing, as the active ingredi ent, ultralow concentrations of antibodies, proteins produced by immune system cells (lymphocytes). Antibodies are glycoproteins with a complex structure and high molecular weight (150 kDa) belonging to a special class of biomolecules-immunoglobulins. The ability of antibodies to specifically interact with other proteins (antigens) ensures their participation in the anti infection defense, as well as enables their use in regulation of the immune system and in maintaining homeostasis of an organism as a whole. At present, for drugs based on ultrahigh dilutions of antibodies, the safety, efficiency [5][6][7][8], and specific pharmacological effect [9] have been proved at the preclinical and clin ical levels; however, physicochemical causes of their impact on the living organism is not yet clear.In attempts to physicochemically explain the bio logical activity of ultrahigh dilutions, it is logical to use the previously developed approach and understanding of the causes behind the physicochemical properties and biological effects of solutions in the range of lower dilutions corresponding to 10 -20 -10 -6 mol/L [1,2]. This work is aimed at studying, under ambient con ditions and at decreased levels of external physical fields (in a permalloy container), the self organization and physicochemical properties of highly diluted aqueous solutions of polyclonal antibodies to the pro tein interferon gamma. We also intend to establish the correlation between the self organization of high...

A new water-soluble resorcinarene, with a negatively-charged lower rim and a positively-charged upper rim self-assembles into supramolecular oligomers to bind 1,5-diaminonaphthalene in water.

The aggregation in aqueous solutions of alkylated 1,4 diazabicyclo[2.2.2]octanes of various hydrophobicity and their adsorption at the water-air interface were studied by tensiometry, conductometry, potentiometry, viscosimetry, and ESR spectroscopy. The parameters of ad sorption, critical micelle concentrations, concentrations of free counterions (bromide ions), and degree of binding of the counterions with micelles were determined. The intensification of the micelle formation ability of the surfactants with an elongation of the alkyl fragment was shown. The effective radii of ensembles of the hexadecyl and octadecyl derivatives were deter mined by the dynamic light scattering method. A relationship between the concentration de pendences of the size of micelles and their shape was established.

No abstract

No abstract