suboptimal VAC. In both other groups proportions of subjects with baseline Ea/Ees values < 0,5 and 0,5-1,0 was equal.Conclusions: Cardiac adaptation to increased afterload in untreated hypertensive subjects is variable. HIE reveals further VA uncoupling in subjects with baseline Ea/Ees < 0,5 due to disproportional decrease of Ees and increase of Ea.Objective: To assess angiotensin I (AT-I) and aldosterone (AS) secretion and left atrial (LA) size in essential hypertensive persons depending on left ventricular ejection fraction (LVEF) in normal diapason of values.Design and method: 62 subjects with mild-moderate essential hypertension (mean age 59,65 ± 9,85 yrs) with LVEF equal to or greater than 50% were divided in 2 groups. LVEF was calculated according to Penn Convention formula. The 1st group: 35 persons (19 m, 16 f) who had LVEF equal to or greater than 60% (mean 66,5 ± 5%); the 2nd group: 27 persons (15 m, 12 f) who had LVEF equal to or greater than 50 and less than 60% (mean 53 ± 6,6 %). The 3rd group (control) consisted of 25 normotensive patients (13 m, 12 f) without cardiovascular pathology (mean age 55,6 ± 16,3 yrs, mean LVEF 67,1 ± 4,2 %). Transmitral parameter of diastolic function (Ve/Va, units) was the lowest in the 2nd group persons in comparison with 1st and 3rd groups patients (p < 0,05 for both). There were investigated AT-I (ng/ml) and AS (pkg/ml) plasma levels (radioimmunoassay method), LA volume, indexed by body surface area (LAVI, ml/m 2 )). Data are specified as mean ± standard deviation or as percent.
Results:The 2nd group patients had the highest both hormones levels, but AT-I and AS secretions were in normal range in each group (1st group: 0,67 ± 0,1 and 70,4 ± 29,1; 2nd group: 0,82 ± 0,2 and 91,3 ± 22,3; 3rd group: 0,44 ± 0,6 and 54,3 ± 22). Differences between 1st and 3rd groups: p > 0,05 for AT-I and AS. The 1st vs the 2nd: p = 0,04 for AT-I and p < 0,01 for AS. The 2nd vs the 3rd: p = 0,02 for AT-I and p < 0,001 for AS. The 2nd group patients had the highest LAVI (1st group: 21,7 ± 4,7; 2nd group: 29,7 ± 6,2; 3rd group: 20,3 ± 4,2). The 1st vs the 3rd: p = 0,07; the 2nd vs the 3rd: p = 0,01; the 1st vs the 2nd: p = 0,02.Conclusions: Essential hypertensive persons with LVEF equal to or greater than 50 and less than 60% are characterized by much more angiotensin I and aldosterone secretion and LA size than hypertensive or normotensive subjects with LVEF equal to or greater than 60%.