This work aims to evaluate the prognostic value of the demographical and clinical data on long-term outcomes (up to 12 months) in patients with severe acquired brain injury with vegetative state/unresponsive wakefulness syndrome (VS/UWS/UWS) or a minimally conscious state (MCS). Patients (n = 211) with VS/UWS/UWS (n = 123) and MCS (n = 88) were admitted to the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology after anoxic brain injury (n = 53), vascular lesions (n = 59), traumatic brain injury (n = 93), and other causes (n = 6). At the beginning of the 12-month study, younger age and a higher score by the Coma Recovery Scale-Revised (CRS-R) predicted a survival. However, no reliable markers of significant positive dynamics of consciousness were found. Based on the etiology, anoxic brain injury has the most unfavorable prognosis. For patients with vascular lesions, the first three months after injury have the most important prognostic value. No correlations were found between survival, increased consciousness, and gender. The demographic and clinical characteristics of patients with chronic DOC can be used to predict long-term mortality in patients with chronic disorders of consciousness. Further research should be devoted to finding reliable predictors of recovery of consciousness.

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Introduction: During experimental studies of structural steels responsible for the reliability of metal structures used, for example, in hoisting and transporting machinery, we established a correlation between the magnetic parameter Hp and characteristic changes in the metal microstructure during thermal cycling. It is shown that the Нр parameter depends on the initial structural state of steel, the amount and mass fraction of alloying elements, and the number of heating/cooling cycles. Methods: We found that an increase in the number of heating/cooling cycles and the amount of alloying elements, as well as preliminary cold plastic deformation with stage-by-stage control of structural changes using passive magnetic flux leakage testing results in a finer-grained structure, which was confirmed by metallographic analysis. Results: The paper considers specifics of structural changes in steels with different initial structures during thermal cycling. It is shown that the final grain size depends on the number of treatment cycles, the amount of alloying elements, and the initial microstructure. It is the fine-grain structure that improves the most important performance characteristics of steels: strength, cyclic strength, and cold brittleness.

CASP checklists. The success characteristics were extracted from the eligible articles. Results: The search returned with 1833 articles with 944 excluded for duplicates, non-relevance, study design and endpoints, and publication types after initial review. Preliminary result showed that diabetes, cardiology and obesity were the most common target disease areas for digital technology implementation. The most used digital technology were mobile applications, wearables, and web-based intervention, with artificial intelligence is increasingly studied. Publications on industry-sponsored trials, digital technology in clinical trials and as specific treatment companion are limited. The endpoints for outcome measurement and result of digital technology in improving patients' quality of care vary. The success factors for digital technology implementation are quality of care achievement (effective, efficient, accessible/ coverage, and standardized) and positive user experience (usability, acceptability, non-interference and reliability). Conclusions: Digital technology is increasingly used in healthcare settings and showed promising benefits to measure and improve patient outcome. Patients' insights, system standardization and validation are crucial for the success of digital solution. A standardized and robust study design is required to demonstrate the impact of digital technology on patients' quality of care.

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In the Middle Urals the middle-ripening varieties of spring soft wheat with gluten content of 22–24% and the middle-early and early ripening varieties of spring soft wheat with gluten content of 26–34% are able to form kernels suitable for bread baking of the first, second and third classes. Nowadays a comparative characteristic of the grain quality of the main varieties developed by the of the selection of the Ural RIA included in the State List of the Breeding Achievements in the Volga-Vyatka Region and their abili­ty to form food grain suitable for bread baking is of great practical interest. In the Krasnoufimsky breeding center there were stud­ied 11 spring wheat varieties included in the State List of the Breeding Achievements in the Volga-Vyatka region in the 2013 and 2016 years of arid conditions (90–100 mm of precipitation, 17.0–17.5 ºC of average daily air temperature) and in the years 2014 and 2015 of excessive moisture (294–423 mm of precipitation and 15–16 ºC of average daily air temperature). The early rip­ening varieties “Irgina” and “Iren” (71–94 days of vegetation period) formed an average yield of 2.94 t/ha. The middle-early ripen­ing varieties “Ekaterina”, “Gornouralskaya”, “Svecha”, “Bazhenka”, “Zlata” (75–98 days of vegetation period) produced 3.32 t/ha.The middle-ripening varieties “Krasnoufimskaya 100”, “Ekada 70”, “Simbirtsit”, “Omskaya 36” (90–94 days of vegetation period) pro­duced 3.55 t/ha. The most productive ones are “Iren” (3.05 t/ha), “Ekaterina” (3.64 t/ha), “Ekada 70” and “Simbirtsit” (3.70–3.78 t/ha). Food grain of the first class (with gluten content of more than 32%) was formed by the varieties “Irgina”, “Iren”, “Bazhenka”; the rest varieties formed the second class grain (with gluten content of more than 28%). The ranking method by seven indicators of grain quality allowed us to determine the average rank and to identify the varieties “Irgina” and “Iren” with the highest baking properties (average rank of 1.0–1.7). They are the most promising varieties for the production of food grains in the conditions of the Middle Urals. It is not advisable to use the middle-ripening varieties “Ekada 70” and “Simbirtsit” for this purpose as the average rank of their quality indicators is 7.0–7.1.

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