Study of the proliferative potential and immunophenotype of lymphocytes and cytokine-producing capacity of mononuclear cells in patients with chronic tick-borne encephalitis virus antigenemia showed changes in T cell lymphoproliferative response, relative content of T cells and T helper inductors, immunoregulatory index, and imbalance in the production of immunoregulatory Th1 and Th2 cytokines.
The aim of this work was to assess the lymphocyte transformating responses to stimulation with antigens or mitogens in chronic opisthorchiasis patients with low and high degrees of infection intensity. The heavily infected patients demonstrated the lowest levels of stimulated lymphocyte transformating response in vitro, and CD8+ or CD16+ counts in peripheral blood.
The structure of lymphocyte and erythrocyte plasma membrane in patients with long persistence of tick-borne encephalitis virus was studied using fluorescent probes pyrene and 1-anilinonaphthalene-8-sulfonate. The authors analyze the clear-cut disorders in the membranes of both lymphocytes and erythrocytes in viral tick-borne-encephalitis from the viewpoint of generalized involvement of cell membranes in infectious process.
The aim of the work is to study the efficiency of different antibacterial medication combinations for the treatment of patients with acute Lyme mite borreliosis. 156 patients aged 20—76 have been on regular medical check-up. Different penicillin and tetracycline antibiotics have been applied as well as cephalosporins of 1 and 3 generation. The treatment duration has been 7—14 days. The duration of general intoxication syndrome, terms of clinical symptom dissapearance, antibody titer dynamics in indirect immunofluorescence reaction with borreliosis antigen, presence of side actions and long-term results of the treatment have been taken into account in the evaluation of different antibiotic combination efficiency. 1 year after discharge from the hospital 69,2% of observed persons considered themselves healthy, 15,4% obtained the diagnosis of chronic clinical LMB with predominant joint or nervous system damages. Thus, analysis of the investigation result shows that currently used etiotropic therapy regimens are not sufficiently effective. They allow recovery of 69,2% of patients with acute Lyme mite borreliosis only.
Введение Клещевой энцефалит (КЭ)-одно из самых распространенных природно-очаговых заболева-ний нервной системы. Современный клинический облик данной нейроинфекции связан со способностью вируса длительное время сохраняться в активном состоянии после адекватного лечения острых форм заболевания [3, 5, 6, 8, 10, 12, 13, 21]. К настоящему времени накоплены данные клинико-эпидемиологических и экспериментальных исследований, выполненных с применением современных молекулярно-биологических и иммунологических методов, создающие вполне целостную картину патогенеза острых форм клещевого энцефалита [10, 14, 15, 16, 21, 27, 28]. Вместе с тем обращает на себя внимание незначительное число
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