Antiviral Activity of Jodantipyrin – An Anti-Inflammatory Oral Therapeutic with Interferon-Inducing Properties

Khudoley, Vladimir N.; Saratikov, A. S.; Лепехин, А. В.; Yavorskaya, Valentina E.; Евстропов, А. Н.; Portnyagina, Elena; Помогаева, А. П.; Белобородова, Э. И.; Vnushinkaia, Marina A.; Schmidt, Evgeni V.; Krilova, Nina V.; Хунафина, Д. Х.; Mezenzeva, Marina V.; Ершов, Ф. И.; Raevski, Konstantin K.; Vlasova, E. V.; Abdulova, Gulnara A.; Кропоткина, Е. А.

doi:10.2174/187152308784533195

Cited by 8 publications

(2 citation statements)

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“…Йодантипирин ® является российским противовирус-ным препаратом -индуктором эндогенного интерферо-на (ИФН), который обладает иммуномодулирующей, про-тивовирусной и противовоспалительной активностью при различных вирусных инфекциях, включая клещевой энцефалит (КЭ) и грипп [1,2].…”

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New approaches to emergency prevention and treatment of viral infections by the example of tick-borne encephalitis and influenza

Лепехин¹,

Ilyinskikh²,

Lukashova³

et al. 2016

Med. sov.

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unclassified

New approaches to emergency prevention and treatment of viral infections by the example of tick-borne encephalitis and influenza

Лепехин¹,

Ilyinskikh²,

Lukashova³

et al. 2016

Med. sov.

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“…Despite that vaccines are available against tick-borne encephalitis virus (TBEV), YFV, and JEV, 9 they can be used successfully only as prophylaxis measure before the infection. Other treatment options include symptomatic treatment schemes and immunoglobulin therapy of tick-borne encephalitis cases, 10 several immunomodulating agents (e.g., jodantipyrin 11 and luromarin 12 ) are on a preclinical stage, but their applicability in the course of flaviviral infection is limited. Moreover, in the case of Omsk hemorrhagic fever virus (OHFV), Powassan virus (POWV), and other locally important flaviviruses, specific vaccines development would never be done due to a small number of cases.…”

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confidence: 99%

Inhibitors of Tick-Borne Flavivirus Reproduction from Structure-Based Virtual Screening

Osolodkin

Kozlovskaya

Dueva

et al. 2013

ACS Med. Chem. Lett.

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Flaviviruses form a large family of enveloped viruses affecting millions of people over the world. To date, no specific therapy was suggested for the infected people, making the treatment exclusively symptomatic. Several attempts were performed earlier for the design of fusion inhibitors for mosquito-borne flaviviruses, whereas for the tick-borne flaviviruses such design had not been performed. We have constructed homology models of envelope glycoproteins of tick-transmitted flaviviruses with the detergent binding pocket in the open state. Molecular docking of substituted 1,4-dihydropyridines and pyrido[2,1-b][1,3,5]thiadiazines was made against these models, and 89 hits were selected for the in vitro experimental evaluation. Seventeen compounds showed significant inhibition against tick-borne encephalitis virus, Powassan virus, or Omsk hemorrhagic fever virus in the 50% plaque reduction test in PEK cells. These compounds identified through rational design are the first ones possessing reproduction inhibition activity against tick-borne flaviviruses.

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Small molecule-based inhibitors for treatment of tick-borne encephalitis virus infection: Nucleoside analogs and nonnucleoside antivirals

Thames

Eyer²,

Seley‐Radtke³

2022

Annual Reports in Medicinal Chemistry

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Antiviral Activity of Jodantipyrin – An Anti-Inflammatory Oral Therapeutic with Interferon-Inducing Properties

Cited by 8 publications

References 0 publications

New approaches to emergency prevention and treatment of viral infections by the example of tick-borne encephalitis and influenza

New approaches to emergency prevention and treatment of viral infections by the example of tick-borne encephalitis and influenza

Inhibitors of Tick-Borne Flavivirus Reproduction from Structure-Based Virtual Screening

Small molecule-based inhibitors for treatment of tick-borne encephalitis virus infection: Nucleoside analogs and nonnucleoside antivirals

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