The effect of cadmium chloride on lipid peroxidation in the liver, kidneys, brain, and gonads of outbred albino rats was studied in winter and summer. Cadmium chloride in a daily dose of 2 mg per 100 g body weight was administered intragastrically for 15 days. Administration of cadmium chloride was followed by an increase in peroxide radical production in the liver during the summer period. Lipid peroxidation remained unchanged in the liver, but increased in the ovaries of animals receiving the same dose of cadmium chloride during the winter period.
Резюме. Цель. Аркуатное ядро (АЯ) гипоталамуса является одним из интегративных центров, ответ-ственных за энергетический метаболизм млекопитающих. Изучена реакция АЯ белых крыс на токсиче-ский стресс, вызванный введением хлорида кадмия в условиях естественного освещения, световой и темновой деприваций. Методы. Токсикант вводили перорально в дозе 2 мг на 100 г массы тела еже-дневно в течение 15 дней после месяца адаптации к искусственному фоторежиму. Синтетическую ак-тивность оценивали методом кариолометрии на окрашенных гематоксилином и эозином срезах гипота-ламуса. Результаты. Как световая, так и темновая депривации приводили к уменьшению размеров нуклеол АЯ у животных обоего пола. Соль кадмия в условиях естественного освещения вызвала уменьшение размеров нуклеол, но только у самцов. Напротив, на фоне темновой депривации хлорид кадмия приводил к снижению активности АЯ только у самок. Световая депривация способствовала уве-личению синтетической активности нейроцитов АЯ под действием соли кадмия у самцов, но не изменя-ла таковую у самок. Заключение. Влияние токсического стресса, вызванного введением хлорида кад-мия, на гипоталамический центр, ответственный за энергетический метаболизм организма, зависит от режима освещенности и пола животного. Угнетение синтетической деятельности АЯ хлоридом кадмия при естественном освещении более выражено у самцов, а при темновой депривации -у самок. Ключевые слова: гипоталамус, аркуатное ядро, фоторежимы, кадмий, токсический стресс.Формат цитирования: Котельникова С.В., Котельников А.В., Зайцев В.Ф. Влияние токсического стресса на морфофункциональное состояние аркуатного ядра гипоталамуса в условиях измененного режима освещенности // Юг России: экология, развитие. 2016. Т.11, N2. C. 185-191. DOI: 10.18470/1992185-191. DOI: 10.18470/ -1098185-191. DOI: 10.18470/ -2016 Abstract. Aim. Arcuate nucleus (AN) of the hypothalamus is one of the integrative centers responsible for energy metabolism in mammals. Reaction of the arcuatus nucleus of white rats on the toxic stress caused by introduction of cadmium chloride in the conditions of natural illumination, light and dark deprivations was studied. Methods. The toxicant was entered per os at a dose of 2 mg on 100 g of body weight a daily for 15 days after one month of adaptation to an the artificial photomode. Synthetic activity was estimated a method nucleoli volumes' measurement on hematoxylin and eosin sections of the hypothalamus. Results. As light and dark deprivations led to the reduction of the nucleoli volumes of AN at animals of both sexes. Salt of cadmium in the conditions of natural illumination has caused reduction of the nucleoli sizes, but only in males. On the contrary, on the background of dark deprivation THE IMPACT OF TOXIC STRESS ON THE MORPHOFUNCTIONAL STATE OF THE HYPOTHALAMIC ARCUATE NUCLEUS IN THE CONDITIONS OF THE CHANGED MODE OF LIGHT EXPOSURE
The articlestudies the influence of treatment-and-prophylactic specimen ES-2 (extract of sapropel) onto the fish-breeding, biological and physiological-biochemical parameters of eugamic tilapia hybrid species Oreochromis spp. carried out in the Innovative centre "Bio-Aquapark - Scientific and Technical Center of Aquaculture" of Astrakhan State Technical University. Fishes (in the amount of 15 species) were kept in aquariums with water volume of 20 litres with artificial aeration, filtration and heating. High density of seeding facilitated studying the influence of specimen on the degree of fish resistance to water environment pollution by waste products. In the course of the experiment (30 days) parameters of the water environment (temperature, pH, content of oxygen, nitrites, free ammonia) were under control. According to the results, all fish-breeding and biological parameters were better among fish species from the pilot group, which got food including sapropel extract. Survivability of fish under experiment made 100%, of those under control - 87%. The absolute increase in body mass of fish in the experimental group (28.83 g) was by 5.06 g higher than in control group. The average daily gain was also higher in fish from the experimental group and amounted to 0.96 g while in the control group it was lower - 0.79 g. Feed conversion ratio in experimental group was lower (1.2) than in control group (1.3), which shows better assimilation of feed by fish species from the experimental group. Concentration of hemoglobin in fish species of both groups differed lightly, but in experimental group it was higher: 90.0 ± 1.81 g/l; in the control group it was 88.32 ± 1.76. In the experimental group there was observed the rise in erythrocyte sedimentation rate that might indicate a change in protein composition of blood plasma due to better nutrition, and can also be a result of acclimation of tilapia to another diet). However, the level of total serum lipids slightly changed: experimental group - 3.41 ± 0.15, control group - 3.46 ± 0.13 g/l; cholesterol level changed within 3.5-3.53 mmol/l, i.e. dynamics of lipid exchange enhanced normal exchange of energy resources. According to the study results, specimen ES-2 is recommended to add to the production food in the course of commercial breeding of tilapia.
Polysaccharides are the most widely used biopolymers in the food industry, for example sodium alginate (food additive E401) taken as an anionic substance. Sodium alginate can act as a thickening agent in jelly-like materials, fillings and gravy products, and as a moisture-retaining ingredient in baked goods and other products. The unique industrial source of sodium alginate in modern conditions is sea brown algae (kelp and fucus). In the Caspian basin Ectocarpus algae can be attributed to the brown algae species rich in alginates. Dry Ectocarpus served as the object of scientific analysis. At present, the emergence of new information on the pharmacological parameters of a number of algae biocomponents has led to an increased interest in the study of technological approaches to the production of functional food substances and their biologically active substances. At the same time, algae can act as a raw material base for producing both independent materials and their derivatives in the form of food premixes leading to an increase in the quality indicators of basic materials while maintaining taste sensations or improving the structural organization, external state and increasing storage time. The purpose of this study was to identify the static patterns of the ratio of the extractant masses and the object of study and the kinetics of extraction of the target components from the dry Ectocarpus with a aqueous-alcohol composition to determine the efficiency and rational time of this operation. The type of kinetic dependences of extraction does not contradict the approved and published data in this field with certain specifics for the product under study and the conditions for this operation. This determines the rationality of the original approaches to improve the efficiency of algal raw materials extraction in the above-mentioned extractant environment.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.