Objective: to study the features of lipid spectrum of blood serum in patients with hypothyroidysm and thyrotoxicosis depending on age, degree of compensation, duration of the illness and body mass index (BMI). Materials and methods . 70 patients with thyroid dysfunctions with various degree of compensation were included in the study. They were divided into 3 groups: the first group with primary subcompensated and decompensated hypothyroidysm; the second group with primary subcompensated and decompensated thyrotoxicosis, and the third group as a comparison group included patients in the state of medicamental compensation. The laboratory research was aimed at the definition of the indices of cholesterol (chol), triglycerides (TG), high density lipoproteins (HDLP), low density lipoproteins (LDLP), very low density lipoproteins (VLDLP) and quotient aterogenesity (QA) on the biochemical machine «Architect с8000» (ABBOOT, USA). Results. The analysis of the lipid spectrum depending on age in patients under 40 and over 50 revealed higher indices of chol and TG in the first group, than in the third one. The patients of the second group under 49 and over 60 had the same indices lower than in the patients of the third group. The patients of the first group who were in the state of decompensation observed the maximum indices of chol, TG, LDLP, VLDLP and QA. The patients of the second group in the state of decompensation had minimum deflection of the same indices of lipid spectrum. The patients of the first group observed increased indices of chol and TG in augmentation of the illness experience and the patients of the second group had the same indices decreased. The comparison of the data revealed minimum chol indices in the patients of the second group, and maximum TG indices in the first group in normal, boundary and increased BMI. Conclusion. The state of lipid spectrum in the patients with thyroid dysfunctions depended on the age of the patients, the experience of the illness, and BMI and compensation degree of thyroid functions which was confirmed by authentic correlation communications between the indices of free thyroxin and chol, TG and LDLP, and also between the thyroid stimulated hormone level and chol, TG, QA, LDLP and VLDLP indices.
There are the hormonal and metabolic disorders during the elderly of organism. The most important of them are the thyroid dysfunctions. Hypothyroidism is difficult to diagnose in old age, because it has many clinical «masks». But undiagnosed hypothyroidism leads to degenerative changes in cardiovascular system and central neural system, exceeding early elderly and human social disadaptation. That’s why preliminary diagnostic and adequate correction of hypothyroidism can prolong active life in elderly.
The known hormonal-metabolic changes lead to developing first of all senior cardiopathy and encephalopathy in the elderly. Encephalopathy doesn’t equal to senior dementia. Thyroid pathology with manifest or subclinical hyperthyroidism exceeds the heart and brains dystrophy complicated arrhythmias and early developed chronicle cardiac failure. It requires the ability to diagnose hyperthyroidism in elderly to treat it correct and early.
The echocardiographic indices and electrocardiographic changes of lipid blood spectrum in patients with tyroidcardiomyopathias have been analyzed. Cardiomyopathia in hypothyrosis is characterized by hypertrophy of left ventricle with diastolic dysfunction and hydropericardium. Tyrotoxiccardiomyopathia is characterized by dilatation of left atrium, hypertrophy of left ventricle, dilatation of right ventricle, lung hypertension. The systolic pressure in lung artery in the patients with hypothyrosis is reliably higher and right ventricle is reliably larger. The patients with hypothyrosis revealed a reliable increase of cholesterol at the expense of low-dense lipoproteids. The content of triglycerides and high-dense lipoproteids did not differ.
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