State of Blood Serum Lipid Spectrum in Thyroid Dysfunctions

Abstract

Objective: to study the features of lipid spectrum of blood serum in patients with hypothyroidysm and thyrotoxicosis depending on age, degree of compensation, duration of the illness and body mass index (BMI). Materials and methods . 70 patients with thyroid dysfunctions with various degree of compensation were included in the study. They were divided into 3 groups: the first group with primary subcompensated and decompensated hypothyroidysm; the second group with primary subcompensated and decompensated thyrotoxicosis, and the third group as a comparison group included patients in the state of medicamental compensation. The laboratory research was aimed at the definition of the indices of cholesterol (chol), triglycerides (TG), high density lipoproteins (HDLP), low density lipoproteins (LDLP), very low density lipoproteins (VLDLP) and quotient aterogenesity (QA) on the biochemical machine «Architect с8000» (ABBOOT, USA). Results. The analysis of the lipid spectrum depending on age in patients under 40 and over 50 revealed higher indices of chol and TG in the first group, than in the third one. The patients of the second group under 49 and over 60 had the same indices lower than in the patients of the third group. The patients of the first group who were in the state of decompensation observed the maximum indices of chol, TG, LDLP, VLDLP and QA. The patients of the second group in the state of decompensation had minimum deflection of the same indices of lipid spectrum. The patients of the first group observed increased indices of chol and TG in augmentation of the illness experience and the patients of the second group had the same indices decreased. The comparison of the data revealed minimum chol indices in the patients of the second group, and maximum TG indices in the first group in normal, boundary and increased BMI. Conclusion. The state of lipid spectrum in the patients with thyroid dysfunctions depended on the age of the patients, the experience of the illness, and BMI and compensation degree of thyroid functions which was confirmed by authentic correlation communications between the indices of free thyroxin and chol, TG and LDLP, and also between the thyroid stimulated hormone level and chol, TG, QA, LDLP and VLDLP indices.