Introduction. People living with HIV (PLWH) have a great need in physical therapy (PT), but there are many barriers to accessing it. Specific recommendations on how to integrate PT into multidisciplinary teams and outpatient care programs PLWH is currently in short supply.
The aim of the study. Identify factors to consider when integrating PT into the work of a multidisciplinary team in providing assistance to PLWH.
Materials and methods. A descriptive sociological study consisting of interviews with health workers (n=12) and with adults living with HIV (n=13).
Research results and their discussion. Guided by the principles of biopsychosocial models in the study of barriers and factors to be considered when integrating PT in multidisciplinary team for the management of PLWH, identified 8 contextual factors that may affect the integration of PT in the care of PLWH.
Conclusion. The role of PT in the care of PLWH is multifactorial and patient-oriented, a special role belongs to the contextual factors.
Prospects for further research. Structuring the PT mode with orientation on a specific patient; development of methods for assessing PT as an interprofessional component assistance.
Coronavirus disease 19 (COVID-19) is a global health crisis on a planetary scale. COVID-19 in many people has mild or moderate manifestation, although significant number of people, especially the elderly, suffer heavy from this illness, which often resulting in death. There are reports of similarities in immune response between COVID-19 and some autoimmune diseases. Earlier, we have demonstrated that fraction of TCA-soluble blood serum proteins containing a 48 kDA fragment of unconvential Myosin C1 have linked with development of multiple sclerosis and rheumatoid arthritis. Here we analyze use of these proteins in determining the severity of disease in COVID-19 patients. We found that blood serum of COVID-19 patients in acute disease manifestation contains, in contrast to healthy individuals, the TCA-soluble proteins with molecular masses 48 kDa and 76 kDA which were identified as a short form of unconventional myosin 1c and a modified form of human serum albumin.
Purpose: to assess the functional state of patients with human immunodeficiency virus with different levels of T-lymphocytes for use in the practice of physical therapy.
Materials and methods. We examined 24 patients with human immunodeficiency virus at the stage of acquired immunodeficiency syndrome at the outpatient stage of treatment. The patients were divided into 2 groups. Group 1 included 11 patients with CD4+ T-lymphocyte levels <100 cells ml-1, and group 2 included 13 patients with CD4+ T-lymphocyte levels above 150 cells ml-1 (р<0.01). The clinical and anamnestic data, the main anthropometric parameters and physiological indices, the results of carpal dynamometry, the 6-minute walk test, characterizing the functional state of people living with the human immunodeficiency virus, were studied. The results of immunological, virological and biochemical parameters were also studied.
Results. Anthropometric indicators: Group 1 – body mass index 48.9±7.4 kg m2-1, waist to hip ratio ratio 0.92±0.17 cm, leg circumference 16.6±0.8 cm; Group 2 – body mass index 23.1±2.8 kg m2 -1, waist to hip ratio ratio 1.14±0.11 cm, leg circumference 15.9±1.4 cm (р>0.05 ). Indicators of physiological indices: Reed - group 1 - 17.3±7.2%, group 2 - 18.3±11.8% (p>0.05); Hobbes - group I 70.9 ± 5.5%, group 2 - 93.6 ± 11.8% (p<0.05), Kerdo - group 1 was 26.6 ± 14.2%, group 2 - 10 .8 ± 14.7% (р<0.05). Index of functional changes group 2 - 2.44±0.2 points, group 2 - 2.59±0.3 points (p>0.05). Dynamometry indicators - group I - 17.5 ± 6.8 kg, group 2 - 28.1 ± 9.4 kg (р>0.05); strength index – group 1 35.3±-9.6%, group 2 40.5±10.4% (р>0.05); 6 min walk test in group 1 - 402.8±40.04 m, group 2 459.7±56.1 m (р<0.05). Indicators of biochemical studies were in reference values ??in patients of both groups.
Conclusions. There is a decrease in the functional state and the predominance of catabolic processes in people with human immunodeficiency virus with a significant deficiency of CD4+ T-lymphocytes.
Blood sera of 12 severe Covid-19 patients and 14 healthy human donors were subjected to original TCA-extraction/acetone-precipitation followed by SDS-PAAG electrophoresis and mass-spectrometry. 76 kDa protein was detected as one of the differentially expressed proteins in the samples of Covid-19 patients. This 76 kDa protein was identified with mass-spectrometry as human serum albumin. Such molecular form of albumin was absent in blood serum of healthy human donors. The potential ways of generation of the unusual form of human serum albumin and its probable diagnostic value were discussed. Keywords: acetone-precipitation, biomarker proteins, COVID-19, electrophoresis, mass-spectrometry, TCA-extraction, unusual form of human serum albumin
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