Introduction: Hepatitis can be defined as inflammation of the liver. Hepatitis may be acute or chronic. It is estimated that in 2017, approximately 15 million people suffered from Hepatitis in Pakistan suffering from hepatitis. 150–200 million people, or approximately ~3% of the world's population, are living with chronic Hepatitis C. Methodology: A descriptive cross-sectional study was conducted on 300 patients selected by purposive sampling who were reported with Hepatitis-C and co infection of Hepatitis-C + Hepatitis-B, at a tertiary care hospital Gambat. A series of questions were asked from reported patients regarding symptoms and compliance. Results: The results were analyzed by using SPSS-22. Among the 300 patients some were on sofosbuvir (n=150, 50%), which the others were on interferon (n=150, 50%). The findings showed that most of the patients on interferon were non-compliant (n=125,83.3%), and only (n=25, 16.7%) are compliant. Among non-compliant factors, fear from injection was reported in (n=42, 33.6), technique for injection (n=38, 30.4%), prolong duration of action (n=35, 28%), adverse drug reaction (n=26, 20.8%). Better compliance was observed with sofosbuvir (n=93, 62.8%) and non-compliant were (57, 38%). Conclusion: This study concluded that better compliance was achieved with sofosbuvir as compared to interferon, rate of ADR’S were also less with sofosbuvir.
Objective: The purpose of this study to observe the impact of flood on the prevalence of water borne disease. Methodology: A cross sectional observational study was conducted from July 2022 to September 2022 in flood affected areas of district Khairpur Mirs, Pakistan. The study was conducted on 910 patients after taking informed consent. Results: In this study 61% patients were males, 36% were female whereas only 3% participants were transgender. Majority of the patients belongs to rural areas while few belong to urban areas. Majority of the patients were of 01 to 10 years of age while only 43 patients were of age from 71- 80 years. Disease wise 397 case were of malaria, 156 patients were of diarrhea, 75 patients were of dysentery, 66 cases were of cholera, 89 cases were of typhoid fever, 76 cases were of skin diseases, 51 cases were of hepatitis. By keeping in view policy makers can take serious steps to treat the residents of district as well as took preventive measure to rescue the residents of district Khairpur Mirs. Conclusion: This study concludes that due to flood water accumulation water borne diseases increased. Among whole diseases malaria was on top with 44%, diarrhea was on second number with 17% while typhoid was on third number with 10% cases Keywords: Prevalence, Water borne diseases, Flood, Malaria, Diarrhea, Dysentery, Cholera, Typhoid fever, Skin diseases, Hepatitis.
Aim: Candiduria is very common in hospitalized patients. It poses a clinical challenge for the physicians since it is usually asymptomatic. The aim of this study was to identify risk factors associated with nosocomial candiduria in urinary tract infection (UTI) suspected patients in Methodology: Intensive Care Unit (ICU) and to determine their antifungal sensitivity profile. The urine specimens (168) were collected, microscopically screened for presence of yeast, cultured and analyzed for counting, isolation, phenotypic identification of Candida albicans. and testing antifungal resistance profile. Data regarding age, gender, use of catheter, use of antibiotics, diabetes mellitus among patients was also recorded. Results: Out of 168 specimens, C. albicans were isolated from 69 specimens, whereas 20 specimens showed other Candida spp. Age >45 years, gender female, previous use of antibiotics, urinary catheterization, stay in ICU >1 week were found the main predisposing factors (p<0.05) responsible for developing nosocomial candiduria. All C. albicans isolates were found either susceptible or susceptible-dose dependent to fluconazole, amphotericin B and voriconazole; however, 62.32% of the isolates were resistant to itraconazole. Conclusion: Most frequent candiduria, possible predisposing factors in ICU patients and resistance of C. albicans towards itraconazole is alarming and highlights the need of candiduria surveillance.
Aim: Multidrug resistance (MDR) is a major public health problem worldwide. The aim of this study was to assess the prevalence, levels of antimicrobial susceptibility and extended-spectrum beta lactamase (ESBL) production by Escherichia coli O157: H7. Methodology: A cross sectional study was performed and a total of 116 stool samples were collected from children aged ≤ 5 years presenting diarrhoea from hospital located at district Khairpur. E. coli O157: H7 was isolated on Sorbitol MacConkey agar and isolates were initially characterized by Gram staining. Subsequently biochemical characteristics except oxidase test (which was performed manually) and drug sensitivity test was performed by using Automated MicroScan® walkaway machine. ESBL production by isolates was determined by disc diffusion method as per Clinical & Laboratory Standards Institute (CLSI) guidelines. Results: Out of 116 diarrheal samples tested, 16 (13.79%) samples were positive for E. coli O157:H7. High number of E. coli O157: H7 were isolated from children aged up to 1 year followed by 2-3 years aged. Isolates were frequently found in summer season (12 times) followed by winter (3 times) and Autumn (1 time). The isolates were found 100% resistant against Nalidixic acid, Imipenem, Amoxycillin /Clavulanic Acid, Norfloxacin, Chloramphenicol, Vancomycin, Doxycycline, and Ampicillin and 90% resistant to Cifixime. ESBL production was noted in 12 (75%) out of 16 E. coli O157:H7 isolates as confirmed by CLSI protocol. Conclusion: This study revealed that E. coli O157: H7 should be considered as major pathogenic bacterium causing diarrhea in children less than three years. The prevalence of ESBL producer MDR E. coli O157: H7 is of great concern, which requires monitoring of infection control measures through efficient antimicrobial management to ensure an uncompromised public health.
A major issue is that the dissolution and assay methods are not discussed in any pharmacopeia, so the assay method was developed following the guidelines of the Food and Drug Administration. The analytical and dissolution methods were developed and validated in accordance with the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use’s (ICH) guidelines. This study aims to discover the presence of counterfeit or substandard drugs in the market, to classify the most compliant brands, and to ascertain the appropriateness of interchangeability. Four different brands of rivaroxaban were selected in order to perform different quality control tests, which included the analytical, dissolution, and assay methods in accordance with the guidelines of the United States Pharmacopeia. The four chosen brands were tested and the results were found to be compliant with chemical parameters such as dissolution, content uniformity, and assay. Hence, it can be concluded that rivaroxaban 10 mg tablets, manufactured in Pakistan by leading pharmaceutical companies, are consistent in quality and can be easily interchangeable.
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