A regioisomer of the known flavanolignan (-)-silandrin (3a), named (-)-isosilandrin (8a), was isolated from the fruits of a white-flowered variant of Silybum marianum L. populated in Hungary. Its structure was established both by spectroscopic methods and total synthesis, and its absolute configuration was determined by means of circular dichroism. This compound showed stronger inhibitory activity on the superoxide anion (O2*-) release by human polymorphonuclear leukocytes (PMNL) than (+)-silybin (1a,b).
On page S6 there were confusing mistakes in the structural formulas of silybin, isosilybin, silandrin and isosilandrin, in Fig. 1: stereochemistry at C-2 0 and C-3 0 was inverted and at C-5 0 there was an additional OH group. The correct structures are shown below, and some additional structural formulas were also inserted to achieve a complete compilation of Silybum marianum flavanolignans.The online version of the original article can be found under
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