New Components from Silybum marianum L. Fruits: A Theory Comes True

Nyiredy, Szabolcs; Szűcs, Zoltán; Antus, Sándor; Samu, Zsuzsanna

doi:10.1365/s10337-008-0722-3

Cited by 10 publications

(9 citation statements)

References 9 publications

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“…Similarly, milk thistle is commercially cultivated for its remarkable medicinal values [ 6 ]. It has been reported that polyphenols existing in milk thistle seeds have antioxidant, anti-inflammatory, hypolipidemic, and anti-carcinogenic properties, all at once [ 7 , 8 , 9 , 10 ]. Milk thistle seed oil has also been documented as a potential natural source of vitamin E (fat-soluble vitamin covering a set of eight organic molecules, four tocopherols, and four tocotrienols) [ 11 , 12 ], and has often been recommended as a favorable edible oil [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Tunisian Milk Thistle: An Investigation of the Chemical Composition and the Characterization of Its Cold-Pressed Seed Oils

Meddeb

Rezig

Abderrabba

et al. 2017

IJMS

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In this study, milk thistle seeds growing in different areas in Tunisia were cold pressed and the extracted oils were examined for their chemical and antioxidant properties. The major fatty acids were linoleic acid (C18:2) (57.0%, 60.0%, and 60.3% for the milk thistle seed oils native to Bizerte, Zaghouan and Sousse, respectively) and oleic acid (C18:1) (15.5%, 21.5%, and 22.4% for the milk thistle seed oils originating from Bizerte, Zaghouan and Sousse, respectively). High performance liquid chromatography (HPLC) analysis showed the richness of the milk thistle seed oils (MTSO) in α-tocopherol. The highest content was recorded for that of the region of Zaghouan (286.22 mg/kg). The total phenolic contents (TPC) of Zaghouan, Bizerte, and Sousse were 1.59, 8.12, and 4.73 Gallic Acid Equivalent (GAE) mg/g, respectively. Three phenolic acids were also identified (vanillic, p-coumaric, and silybine), with a predominance of the vanillic acid. The highest value was recorded for the Zaghouan milk thistle seed oil (83 mg/100 g). Differences in outcomes between regions may be due to climatic differences in areas. Zaghouan’s cold-pressed milk thistle seed oil had a better quality than those of Bizerte and Sousse, and can be considered as a valuable source for new multi-purpose products or by-products for industrial, cosmetic, and pharmaceutical utilization.

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Section: Introductionmentioning

confidence: 99%

Tunisian Milk Thistle: An Investigation of the Chemical Composition and the Characterization of Its Cold-Pressed Seed Oils

Meddeb

Rezig

Abderrabba

et al. 2017

IJMS

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“…Silymarin mainly comprises of silybin and usually contains several minor components with an important biological activities including isosilybin, silychristin, silydianin, 2,3-dehydrosilybin (DHSB), quercetin and dihydroquercetin (taxifolin) and a poorly characterized polymer fraction. Furthermore, the presence and concentration of minor components in silymarin fluctuate depending on subspecies of S. marianum, growing conditions of the plants and age of the extract (Kurkin et al, 2001;Nyiredy et al, 2008;Biedermann et al, 2014). As such, the characterization of the effect of each of the compounds found in silymarin is pertinent to selecting the 'correct' extract for each application.…”

Section: Introductionmentioning

confidence: 99%

Polyphenols from Silybum marianum inhibit in vitro the oxidant response of equine neutrophils and myeloperoxidase activity

Zholobenko

Mouithys‐Mickalad

Modrianský

et al. 2016

Vet Pharm & Therapeutics

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A recent study showed that silymarin, a standardized extract of S. marianum might be used in the prevention of equine laminitis. We investigated the effects of quercetin and some compounds found in silymarin (silybin, taxifolin and dehydrosilybin) on reactive oxygen species (ROS) production and myeloperoxidase (MPO) release by stimulated equine neutrophils (PMNs) and on MPO activity. All compounds (tested between 100 nm and 100 μm) inhibited superoxide anion production by stimulated PMNs in a dose-dependent manner. Dehydrosilybin and quercetin inhibited superoxide production and MPO release from 10 μm. Classical MPO assay showed quercetin as the most potent inhibitor, followed by taxifolin, dehydrosilybin and silybin. SIEFED MPO assay highlighting the binding of tested compounds to MPO showed that only quercetin and taxifolin maintained an efficient inhibition above 90% at 10 μm. Altogether, our results showed a strong inhibition of PMN activation by planar compounds such as quercetin and dehydrosilybin and a strong inhibition of MPO activity by the smallest molecules, quercetin and taxifolin. In conclusion, the compounds from silymarin may be useful for modulating the oxidative response of PMNs, involved in the pathogenesis of laminitis, but further in vivo studies are needed.

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“…They are therefore, a priori, non-stereospecific and non-regioselective, which implies a wide variety of possibilities at the coupling level, and therefore of the isomers formed. Based on this information, the diastereomers of silybin and isosilybin are described as equimolar mixtures reflecting the lack of stereospecificity of the initial radical couplings [76,95]. Among the available experimental data, none confirms the 1: 1 ratio between these diastereoisomeric couples [31,37,88,96,97].…”

Section: Flavonolignans Biosynthesis In Silybum Marianummentioning

confidence: 99%

Biosynthesis and Regulation of Antioxidant Flavonolignans in Milk Thistle

Drouet¹,

Hano²

2021

Antioxidants - Benefits, Sources, Mechanisms of Action

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Mature fruits (achenes) of milk thistle (Silybum marianum (L.) Gaertner, Asteraceae) accumulate high amounts of silymarin, a complex mixture of bioactive antioxidant flavonolignans deriving from taxifolin. Their biological activities in relation with human health promotion and disease prevention have been well described. The conditions of their biosynthesis in planta, however, have long been elusive and thus tend to be a limiting factor for their future applications. Significant advances in understanding their biosynthesis and regulation have been made over the last decade and are outlined in the current chapter.

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New Components from Silybum marianum L. Fruits: A Theory Comes True

Cited by 10 publications

References 9 publications

Tunisian Milk Thistle: An Investigation of the Chemical Composition and the Characterization of Its Cold-Pressed Seed Oils

Tunisian Milk Thistle: An Investigation of the Chemical Composition and the Characterization of Its Cold-Pressed Seed Oils

Polyphenols from Silybum marianum inhibit in vitro the oxidant response of equine neutrophils and myeloperoxidase activity

Biosynthesis and Regulation of Antioxidant Flavonolignans in Milk Thistle

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