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Background: Serum adiponectin is a hormone of adipose tissue that activateslipid metabolism and exertsphysiological functions. Its level usually fluctuates in several metabolic diseases,including renal insufficiency and diabetes; it loses its protective role against diseases and becomes a potentially risk factor for erythroid abnormalities. Objectives: The study was designed to assess the association between adiponectin  hormone, blood erythroid and various parameters in groups of patients. Method:The study included 130 patientsand 42 healthy subjects. Parameters of serum adiponectin, erythropoietin (EPO), red blood cells (RBC), hemoglobin (Hb), hematocrit (Hct), renal function, serum insulin, fasting blood sugar (FBS), glycated hemoglobin % (HbA1c%) and homeostatic model assessment of insulin resistance (HOMA-IR) were estimated in all groups. Result: Statistical analysis showed that high level of adiponectin was significantly associated with erythroid-related variables (EPO, RBC, Hb and Hct) in patients groups when compared with the control. Receiver Operating Characteristic (ROC) curve analysis showed that adiponectin is a significant risk factor for anemia progression in non-insulin dependent diabetes mellitus (NIDDM), end stage renal disease (ESRD)and diabetic nephropathy patients. Conclusion: We suggest that high serum adiponectin level is dependently associated with EPO level and erythroid abnormalities in NIDDM, kidney failure and diabetic nephropathy patients. The present findings regarding ROC curve analysis of adiponectin suggested that this hormone could represent a risk factor for erythroid abnormality in diabetic nephropathy at ESRD.

This study was aimed to investigate the biological association between resistin, adiponectin, visfatin and ghrelin hormones with some coagulation markers. The study included 130 patient and 42 healthy subjects. Serum resistin, adiponectin, visfatin, ghrelin  and some other hematological and biochemical parameters were estimated. Statistical analysis showed that altered resistin, adiponectin, visfatin,  and ghrelin levels were significantly and directly or indirectly through insulin resistance (IR)  associated with clotting markers. From the main studied levels of adipokines, ghrelin, and clotting parameters, the study indicated high levels of serum resistin, adiponectin, visfatin and ghrelin hormones in NIDDM, ESRD, NIDDM+ESRD patients. Also, altered platelets (PLT), mean platelet volume (MPV), prothrombin time (PT), activated partial prothrombin time (aPPT), plasminogen activator inhibitor- 1 (PAI-1), and fibrinogen1 were observed. The studied adipocytokines and ghrelin concentration was correlated directly and indirectly through IR with the studied clotting parameters.

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