Objective
To investigate the association between
IL7R
rs6897932 and multiple sclerosis (MS) in southern Chinese people.
Methods
In total, 147 MS patients and 530 healthy controls were recruited according to the revised McDonald criteria. The TaqMan method was used for genotyping.
Results
With genetic models, we can observe that the additive model, the dominant model, and the recessive model of
IL7R
rs6897932 were significantly associated with MS [additive model:
p
=0.032; dominant model (adjusted):
p
<0.001, OR=3.61 (95% CI 2.25–5.83); recessive model (adjusted):
p
<0.001, OR=6.80 (95% CI 3.49–13.89)].
Conclusion
Our results suggest that
IL7R
rs6897932 is associated with MS in a southern Chinese population. More and larger MS studies to explore the genetic risk factors of MS are warranted.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.