Association between subjective autonomic dysfunction and fatigue in Parkinson’s disease in southern Chinese

Zhao, Zongbo; Liu, Hui; Xue, Jianzhong; Shi, Zhige; You, Nianxing

doi:10.1007/s10072-021-05209-y

Cited by 3 publications

(3 citation statements)

References 18 publications

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“…Additionally, a double-blind, placebo-controlled Figure1. deep breathing I-E test in fatigued and non-fatigued patients study indicated that L-dopa treatment could partially alleviate physical fatigue in PD, and more recent investigations suggest that dopamine agonists may also play a role in mitigating fatigue (21,22). However, this study has some limitations, including a relatively small sample size of patients with advanced disease, which made it challenging to identify significant differences between fatigued and non-fatigued groups (15).…”

Section: Discussionmentioning

confidence: 88%

Autonomic dysfunction and fatigue in Parkinson’s disease: a report from Kenya

Abuga,

Oyungu,

Nyundo

2023

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Section: Discussionmentioning

confidence: 88%

Autonomic dysfunction and fatigue in Parkinson’s disease: a report from Kenya

Abuga,

Oyungu,

Nyundo

2023

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“…Similar results were obtained by Zhao et al in a study including 602 PwPD. Correlations were found between fatigue (as assessed with FSS) and other autonomic domains, including the urinary domain (as evaluated using the Non-Motor Symptoms Scale and SCOPA-AUT) [61]. In a subgroup of PwPD in the PRIAMO study, various non-motor symptoms (NMS) were associated with urinary dysfunction, such as gastro-intestinal symptoms, sleep, pain, and fatigue [4].…”

Section: Discussionmentioning

confidence: 98%

Nocturia and Sleep in Parkinson’s Disease

Diaconu

Irincu

Ungureanu

et al. 2023

JPM

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Background: Nocturia has a high prevalence in Parkinson’s Disease (PD) and is known to be a bothersome symptom for people with Parkinson’s disease (PwPD). Objective: to characterize nocturia in a sample of PwPD, in relation to sleep, fatigue and other non-motor symptoms (NMS). Methods: we assessed 130 PwPD using a comprehensive battery of scales, which includes the Non-Motor Symptoms Questionnaire (NMSQ), International Parkinson and Movement Disorder Society Non-Motor Rating Scale (MDS-NMS), Parkinson’s Disease Sleep Scale version 2 (PDSS-2), Parkinson’s Disease Questionnaire (PDQ-39), The Overactive Bladder Questionnaire-Short form (OABq-SF), and the Parkinson’s Fatigue Scale (PFS-16). Results: according to the positive answers to the item of the NMSQ related to nocturia, patients were divided into PwPD + nocturia, and PwPD − nocturia. Nocturia was reported by 112 patients (86.15%). Quality of life in PwPD + nocturia was worse than in PwPD − nocturia, according to the PDQ-39 scores (13.32 ± 9.00 vs. 26.29 ± 14.55, p < 0.001). Sleep was significantly disturbed in PwPD + nocturia compared to PwPD − nocturia, according to the total scores of various scales, such as PDSS-2, PFS-16. PwPD who complained of nocturia presented higher scores of several NMS. Conclusions: nocturia has a high prevalence in PwPD and it is associated with impaired sleep, fatigue, and reduced quality of life.

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“…Motor symptoms such as rigidity, myotonia and static tremor, as well as non-motor symptoms associated with autonomic impairment, such as cardiovascular diseases, upright hypotension, sleep disorders, and constipation, are the most common clinical manifestations of Parkinson's disease [5][6][7] . Autonomic dysfunction affects 80 percent of Parkinson's disease patients, resulting in a variety of symptoms 8,9 . The quality of life suffers, and in severe cases, sudden death may occur [10][11][12] .…”

Section: Introductionmentioning

confidence: 99%

Based on variability parameters analysis of autonomic function in rats with Parkinson's disease induced by rotenone

Gao

Wang

et al. 2022

Preprint

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Background: Parkinson's disease is a common neurodegenerative disease, and while early detection of cardiovascular symptoms may aid in early diagnosis, there are no definitive markers to assess cardiovascular autonomic damage in Parkinson's disease. Methods: Twenty Sprague Dawley rats were randomly assigned to the experimental (n=12) and control (n=8) groups, and a model of Parkinson's disease was created in the experimental group by stereotaxic injection of rotenone into the substantia nigra compacta and ventral tegmental area. Telemetry implantation was carried out after successful modeling. Equal dosages of saline were injected into control animals at the same places. In both groups of rats, ECG, blood pressure, core temperature, and activity were recorded using a Data Science International implantable physiological signal telemetry device. The time domain, frequency domain, and non-linear analysis were used to examine the blood pressure and heart rate variability of the two groups of rats. Results: The experimental group had higher Detrended Fluctuation Analysis (DFA) of blood pressure signals (systolic, diastolic, and mean arterial pressure), mean arterial pressure, normalized high frequency power (nHF) than the control rats (p<0.05). The experimental group had lower sample entropy (SampEn) of blood pressure signals (diastolic and mean arterial pressure), root mean squared successive differences (RMSSD), normalized lower frequency power (nLF) and total power than the control group (p<0.05). However, the standard deviation, coefficient of variation, and continuous variation in the linear analysis of continuous blood pressure signal between the two groups were not statistically significant (p>0.05). Conclusion: The rats in the rotenone model had significant autonomic dysfunction, and non-linear analysis approaches such as detrended fluctuation analysis and sample entropy were able to discern the diseased condition of the rats more sensitively while processing the continuous blood pressure data.

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Association between subjective autonomic dysfunction and fatigue in Parkinson’s disease in southern Chinese

Cited by 3 publications

References 18 publications

Autonomic dysfunction and fatigue in Parkinson’s disease: a report from Kenya

Autonomic dysfunction and fatigue in Parkinson’s disease: a report from Kenya

Nocturia and Sleep in Parkinson’s Disease

Based on variability parameters analysis of autonomic function in rats with Parkinson's disease induced by rotenone

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