Curcumin is a natural product traditionally used as a spice that has a great potential for being used as a drug of natural origin. The partitioning of curcumin in an aqueous two-phase system composed of the aqueous solutions of poly(vinylpyrrolidone) 10000 (PVP 10000 ) and trilithium citrate was studied at T = 298.15, 308.15, and 318.15 K. The binodal and tie-line compositions were measured and modeled. The tie-line compositions were modeled successfully using osmotic virial and especially e-Wilson and e-NRTL models, where the deviation percent between the calculated and the experimental tie-line mass fractions was found to be in the range of 0.005−0.03 for the e-Wilson model and 0.02−0.05 for the e-NRTL model, which are in the range of the experimental uncertainties. The high values of the partition coefficient (D) showed the high tendency of curcumin to be extracted from a salt-rich to a polymer-rich phase. The minimum and maximum D values of 11.7 and 21.2 were found at T = 318.15 and 298.15 K, respectively. Moreover, the minimum and maximum extraction efficiencies (E%) of ∼81 and 90% were shown at T = 318.15 and 298.15 K, respectively. Both obtained D and E% values decreased by increasing the temperature, and the best partitioning results were obtained for the tie-lines presented in the middle range of the tie-line compositions.
The partitioning of salbutamol drug
in a poly(ethylene
glycol)
6000 + lithium citrate + water system was investigated at T = 288.15, 298.15, 308.15, and 318.15 K. The binodal curves
and tie-line compositions were determined at different temperatures,
and the studied aqueous two-phase system (ATPS) was used to study
the partitioning of salbutamol drug. The results showed that the ability
of the system for two-phase formation increases at higher temperatures.
The good performance of the empirical Merchuk equation was obtained
to model the binodal curves. The tie-line compositions were also fitted
using the Setschenow-type equation and electrolyte Wilson models.
Furthermore, the ability of the studied ATPSs for the extraction of
salbutamol is shown based on the obtained partitioning parameters,
and the partitioning coefficient was increased from the value of ∼0.48
at T = 288.15 K to ∼1.7 at T = 318.15 K. Overall, the studied ATPS can be employed to extract
salbutamol from aqueous medium in a range of biological temperatures.
Salbutamol is a drug used to treat the pulmonary diseases by ameliorate the medium and large airways in the lungs. Partitioning of salbutamol drug on the aqueous two-phase systems (ATPSs) of PEG1000,1500,2000,4000,6000 + trilithium citrate + water was determined at T = 298.15 K. The effect of molecular mass of polymer (MMP) on the binodal and tie-line compositions were studied. Results showed that the biphasic area was extended as the MMP was increased. The salting-out ability were quantified using the Setschenow model, and the binodal curves were modeled by a nonlinear 3-parameter equation. Furthermore, electrolyte Wilson along with the osmotic virial models have adequately been implemented to fit the tie-line compositions. Also, the studied ATPSs were implemented to study the partitioning of salbutamol drug on the salt-affluent and polymer-affluent phases. It is observed that, ATPSs of PEG1000 is premium to extract the salbutamol to the polymer-affluent phase, where, the ATPSs of PEG6000 is more favorable to extract the drug to the salt-affluent phase.
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