The research aimed to investigate the relationship between happiness, subjective well-being, creativity and job performance of primary school teachers in Ramhormoz City. Hence, a sample of 330 individuals was selected through random stratified sampling. The research tools included Oxford Happiness Inventory, Subjective Well-being Scale by Keyes and Magyarmv, Creativity Inventory by Randsip and Patterson Job Performance Inventory. The research employed a correlational method and the data were analyzed using Pearson correlation coefficient and multiple regression analysis. Results indicated that, there is significant relationship between happiness, subjective well-being, creativity and job performance of primary school teachers in Ramhormoz City. The results of regression analysis indicated that, happiness and subjective well-being are the strongest predictors of job performance.

Background: Physical activity is recognized as a basic component of the management of children with obesity. Objectives: The current study aimed at exploring the effect of a 12-week concurrent strength and aerobic training on body composition, glycosylated hemoglobin, fasting blood sugar (FBS), homeostasis model assessment-estimated insulin resistance (HOMA-IR), plasma insulin, high-density lipoprotein (HDL), low-density lipoprotein (LDL), total cholesterol (TC), and triglyceride (TG) between the females with overweight and obesity. Methods: The current semi-experimental study was conducted on 40 females (20 with obesity and 20 with overweight) aged 13 -15 years selected and randomly assigned into four groups. Strength training was performed three days a week each session for 30 minutes at 50% to 80% of 1 repetition maximum (1RM), and aerobic training started from 50% and progressively reached 80% of maximum heart rate. Blood samples and anthropometric parameters were measured before and after practice. Data were analyzed by covariance. P < 0.05 was considered the significance level. Results: Significant changes were observed in body mass index (BMI), weight, body fat percentage (%BF), and skinfold fat after the intervention (P < 0.05). But, no significant changes occurred in FBS, glycosylated hemoglobin, HOMA-IR, plasma insulin, HDL, LDL, TC, and TG (P > 0.05). Conclusions:The current study suggested that concurrent strength and aerobic training can improve body composition of females with overweight and obesity, and normal blood lipid and glucose hemostasis. However, it did not affect glucose hemostasis and lipid profile.

Introduction: Slowing down the process of angiogenesis in the tumor tissue is an emerging area in the treatment of breast cancer. The purpose of this study was to investigate the effect of quercetin supplementation on the expression of key angiogenesis factors in the tumor tissue of mice with breast cancer. Methods: Sixteen female BALB /c mice were injected subcutaneously with estrogen receptor dependent breast cancer cells MC4L2 and divided into two groups of tumor (T) and tumor + quercetin (TQ). The mice in the TQ group were injected subcutaneously with 110 mg/kg quercetin solution for 6 weeks, 3 days a week. Forty-eight hours after the last injection, the animals were killed and their tumors were removed, frozen in liquid nitrogen and stored at-70° C. ΔCt, ΔΔCt, fold change and Mann-Whitney test at the significance level of (P<0.05) were calculated with GENEX software. Results: The results showed that quercetin supplementation significantly decreased the expression of ANGPT-2 (P<0.00), TIE-2 (P<0.00) and VEGF-A (P<0.00) genes in the TQ group compared with the T group. But ANGPT-1 expression increased, although this increase was not significant. Conclusion: Quercetin supplementation may inhibit tumor angiogenesis and breast tumor growth.

Background: About angiogenesis, metastasis of breast cancer and exercise, Many studies have been done in recent decades to better understand of regulatory mechanisms. The purpose of this study was to investigate the Interactive effect of high-intensity interval training (HIIT) and quercetin supplementation (Q) on the expression of key angiogenic factors in tumor tissue of mouse with breast cancer. Methods: Twenty-four female Balb/C mouse were injected with estrogen receptor-dependent breast cancer cells MC4L2 and then divided into three groups of tumor (T), tumor + of high-intensity interval training (TH) and tumor + high-intensity interval training + quercetin (THQ). The TH and THQ groups ran the treadmill 3 days a week for 6 weeks and each session 1 hour. The THQ group received 110 mg / kg quercetin solution for 6 weeks, 3 days a week with training. After completion of the work, the mouse were sacrificed and their tumor tissue removed and frozen in liquid nitrogen And stored at -70 ° C. Expression of TIE-2 and VEGF-A genes was measured by REAL TIME-PCR. ΔCt, ΔΔCt, and Fold change were calculated with the relevant statistical tests at the significant level (P <0.05) by GENEX software. Results: The results showed that THQ interaction significantly decreased the expression of TIE-2 and VEGF-A genes in TH and THQ groups compared to T group. In addition, quercetin in THQ group significantly decreased TIE-2 and VEGF-A gene expression compared to TH group. Conclusion: interaction of HIIT and Q supplementation are probably effective in inhibiting tumor angiogenesis.

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