Most of the world’s population is exposed to highly polluted air conditions exceeding the WHO limits, causing various human diseases that lead towards increased morbidity as well as mortality. Expenditures on air purification and costs spent on the related health issues are rapidly increasing. To overcome this burden, plants are potential candidates to remove pollutants through diverse biological mechanisms involving accumulation, immobilization, volatilization, and degradation. This eco-friendly, cost-effective, and non-invasive method is considered as a complementary or alternative tool compared to engineering-based remediation techniques. Various plant species remove indoor and outdoor air pollutants, depending on their morphology, growth condition, and microbial communities. Hence, appropriate plant selection with optimized growth conditions can enhance the remediation capacity significantly. Furthermore, suitable supplementary treatments, or finding the best combination junction with other methods, can optimize the phytoremediation process.