Due to the limited self‐repairing capacity after peripheral nerve injuries (PNI), artificial nerve conduits are widely applied to facilitate neural regeneration. Exogenous electrical stimulation (ES) that is carried out by the conductive conduit regulates the biological behavior of Schwann cells (SCs). Meanwhile, a longitudinal surface structure counts to guide axonal growth to accelerate the end‐to‐end connection. Currently, there are no conduits equipped with both electrical conduction and axon‐guiding surface structure. Herein, a biodegradable, conductive poly(l‐lactide‐co‐caprolactone)/graphene (PLCL/GN) composite conduit is designed. The conduit with 20.96 ± 1.26 MPa tensile strength has a micropatterned surface of 20 µm groove fabricated by microimprint technology and self‐assembled polydopamine (PDA). In vitro evaluation shows that the conduits with ES effectively stimulate the directional cell migration, adhesion, and elongation, and enhance neuronal expression of SCs. The rat sciatic nerve crush model demonstrates that the conductive micropatterned conduit with ES promotes the growth of myelin sheath, faster nerve regeneration, and 20‐fold functional recovery in vivo. These discoveries prove that the PLCL(G)/PDA/GN composite conduit is a promising tool for PNI treatment by providing the functional integration of physical guidance, biomimetic biological regulation, and bioelectrical stimulation, which inspires a novel therapeutic approach for nerve regeneration in the future.

In recent years, vital signals monitoring in sports and health have been considered the research focus in the field of wearable sensing technologies. Typical signals include bioelectrical signals, biophysical signals, and biochemical signals, which have applications in the fields of athletic training, medical diagnosis and prevention, and rehabilitation. In particular, since the COVID-19 pandemic, there has been a dramatic increase in real-time interest in personal health. This has created an urgent need for flexible, wearable, portable, and real-time monitoring sensors to remotely monitor these signals in response to health management. To this end, the paper reviews recent advances in flexible wearable sensors for monitoring vital signals in sports and health. More precisely, emerging wearable devices and systems for health and exercise-related vital signals (e.g., ECG, EEG, EMG, inertia, body movements, heart rate, blood, sweat, and interstitial fluid) are reviewed first. Then, the paper creatively presents multidimensional and multimodal wearable sensors and systems. The paper also summarizes the current challenges and limitations and future directions of wearable sensors for vital typical signal detection. Through the review, the paper finds that these signals can be effectively monitored and used for health management (e.g., disease prediction) thanks to advanced manufacturing, flexible electronics, IoT, and artificial intelligence algorithms; however, wearable sensors and systems with multidimensional and multimodal are more compliant.

As the largest organ of the human body, the skin has a complex multi-layered structure. The composition of the skin includes cells, extracellular matrix (ECM), vascular networks, and other appendages....

One of the key problems restricting the development and application of flexible piezoelectric sensors is the lack of efficient, simple, and low-cost manufacturing processes and equipment. The resulting devices also have certain limitations in material selection and performance that cannot be overcome. Herein, we innovatively propose to combine the traditional extrusion additive manufacturing and electrospinning process to realize the "one-step" preparation of the functional layer, electrode layer, and packaging layer of the flexible piezoelectric sensor. The obtained sensor has the characteristics of softness, breathability, and waterproofness. Specifically, the thermoplastic polyurethane (TPU)/poly(dimethylsiloxane) (PDMS) composite nanofiber mats by electrospinning were packaging layers. Under the support of electrospinning self-encapsulation, TPU/PDMS mats give the piezoelectric sensor outstanding waterproofness and air permeability. Compared with the traditional preparation methods, this method not only avoids the complexity of multistep manufacturing and manual assembly, facilitating automation processing and mass production, but also endows the sensor with good linearity, high sensitivity (1.7 V/N), fast response time (18 ms), excellent air permeability (400 g/m 2 /day), and outstanding waterproofness. This method provides a method and idea for the manufacture of comfortable, breathable, and waterproof wearable devices.