Fluid flow is strongly affected by fractures in unconventional reservoirs. It is essential to deeply understand the flow characteristics with fractures for improving the production and efficiency of unconventional reservoir exploitation. The purpose of this work is to develop an accurate numerical model to evaluate the transient-pressure response for well intersecting fractures. The meshes generated from Fullbore Formation Micro-Imager (FMI) images ensure an efficient numerical description of the geometries for fractures and interlayers. The numerical simulation is implemented by an inhouse finite element method-based code and benchmarked with drill stem test (DST) data. The results show that three flow regimes appear in the reservoir with fractures within the test period: wellbore afterflow, pseudolinear flow, and radial flow. In contrast, only the wellbore afterflow and radial flow appear for the wells without fractures. The results also reveal that fractures dominate the flow near the wellbore. Verification and application of the model show the practicability of the integrated approach for investigating the transient-pressure behaviors in the unconventional reservoir.
Pharmacological intervention played an important role in the management of tic disorder. Large-scale prescription data for pediatric tic disorder patients in the real-world setting were scarce. The demographic and prescription data of tic disorder were extracted from the electronic medical records database of Beijing Children's Hospital from 2018 to 2020. The intervention choice for outpatient pediatric tic disorder patients was analyzed. A total of 20 417 patients were included, 28.1% (n = 5028) of them did not receive any pharmacological treatment. Over 70% were prescribed with anti-tic medication. For children less than 6 years of age, clonidine adhesive patches (CAPs) and traditional Chinese medicine (TCM) were the common choice. With the age growing, the use of antipsychotics was on the rise; 22% (n = 3389) were prescribed for at least two anti-tic medication, and the most common medication combination group was tiapride and TCM (33.7%), followed by CAP and TCM (22.1%). The clinical intervention choice for tic disorder is highly individualized. The pharmacological choice was influenced by severity, duration of symptom, age, the acceptance of parents and other factors.
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