The clinical intervention choice for pediatric tic disorder patients from a tertiary children’s hospital in China: a large-scale retrospective study based on electronic medical records

Abstract

Pharmacological intervention played an important role in the management of tic disorder. Large-scale prescription data for pediatric tic disorder patients in the real-world setting were scarce. The demographic and prescription data of tic disorder were extracted from the electronic medical records database of Beijing Children's Hospital from 2018 to 2020. The intervention choice for outpatient pediatric tic disorder patients was analyzed. A total of 20 417 patients were included, 28.1% (n = 5028) of them did not receive any pharmacological treatment. Over 70% were prescribed with anti-tic medication. For children less than 6 years of age, clonidine adhesive patches (CAPs) and traditional Chinese medicine (TCM) were the common choice. With the age growing, the use of antipsychotics was on the rise; 22% (n = 3389) were prescribed for at least two anti-tic medication, and the most common medication combination group was tiapride and TCM (33.7%), followed by CAP and TCM (22.1%). The clinical intervention choice for tic disorder is highly individualized. The pharmacological choice was influenced by severity, duration of symptom, age, the acceptance of parents and other factors.

Correlation between Serum Levels of Vitamin A and Vitamin D with Disease Severity in Tic Disorder Children

“…The tic disorders are treated as per the theory of ZangFu organs, pathological factors, and the differentiation of qi and blood. In addition, nondrug treatments such as acupuncture and massage therapy have been confirmed to be safe via meridian circulation sites and acupoints, which diversifies treatment choices for patients [ 5 , 6 ].…”

Construction of clinical medication pathway for children with tic disorder

“…We included ve clinical guidelines for TD from China, Japan, Europe, America, Canada [9][10][11][12][13] , three clinical guidelines for TD comorbid ADHD from Canada, America, England [14][15][16] , three overviews of systematic reviews [17][18][19] that focused on pharmacological interventions for children with TD, two studies on medication adherence for children with TD 20,21 , two comparative studies on e cacy in China 22,23 , and two studies about investigation and demand on medication choice for children with TD [24][25] , and drug data sheets.…”