Now that indications are clearly defined, applications have mostly become standardized and the active mechanisms have been well confirmed, medical ozone application in the form of the low-dose concept, is established and proven as a complementary medical method in the treatment of chronic inflammations or diseases associated with chronic inflammatory conditions.
More than 11,000 systemic ozone treatments in the form of Major Ozone Autohemotherapy (MAH) in 577 patients and ? 47,000 Rectal Insufflations (RI) in 716 patients in various clinical studies are subjected to critical clinical assessment and classification according to the criteria of evidence-based medicine (EBM).
Statistically significant clinical and/or pharmacological improvements without side-effects or adverse reactions are found in all studies; special attention is drawn to maintaining hygiene when working with blood and to the use of ozone-resistent and biocompatible materials.
On summarizing the evidence classification under RCT + CT (Randomized Controlled Trials + Controlled Trials), i.e. Levels Ib and IIa, 12 studies with 657 ozone-treated patients are obtained for MAH and 6 studies with 227 patients for RI.
As a result of the evidence here assessed, the two systemic ozone applications, MAH and RI are part of evidence-based medicine. Both applications are effective, safe and economic.
INTRODUCTION: Fibromyalgia meaning muscle and connective tissue pain it a disorder classified by the presence of chronic widespread pain and a heightened and painful response to gentle touch (tender points).
Other core features of the disorder include debilitating fatigue, sleep disturbance, and joint stiffness.
PURPOSE: The aim of the study is to see the efficacy of ozone in relation to other local anaesthetic and placebo for relief of pain.
MATERIAL AND METHODS: The Study involved 300 patients with classical Fibromyalgia (ACR criteria) age between 45 and 70.
The first group treated only with ozone 2 - 3 x per week for over 4 necks (15 mcgr/mL)
The second group with local anaesthetic /Lidocain 2 % 10- 20 mL)
The third group, placebo.
Several clinical parameters were monitored during a demonstration in 4-6 weeks.
The clinical examination included vital signs, pain using visual analog Scale, Duration of morning stiffness, night pain, NSAID consumption
RESULTS AND CONCLUSION:
1.- Ozone has significant effect in Fibromyalgia in relation to the other two groups.
2.- Function index improved in both groups ozone and anaesthetic.
3.- Ozone treatment is a safe therapy compared to the local anaesthetic.
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