Ozone in Medicine: The Low-Dose Ozone Concept—Guidelines and Treatment Strategies

Viebahn-Hänsler, Renate; Sonia, Olga; Fernández, León; Fahmy, Ziad

doi:10.1080/01919512.2012.717847

Cited by 110 publications

(82 citation statements)

References 10 publications

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“…Further reaction of O 3 with biomolecules generates aldehyde (e.g., 4-hydroxynonenal (4-HNE)) and peroxide (H 2 O 2 and organic peroxides). These byproducts of the reaction act as secondary messengers and induce a further adaptive hormetic responses [56][57][58]. Ozone at a therapeutic dose "only acts" as a modulator or pro-drug and, by inducing secondary messengers, will enhance subsequent adaptive responses [21].…”

Section: Ozone Therapy As Redox Modulatormentioning

confidence: 99%

Potential Cytoprotective Activity of Ozone Therapy in SARS-CoV-2/COVID-19

2020

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1) Background: The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease in China at the end of 2019 has caused a large global outbreak. Systemic ozone therapy (OT) could be potentially useful in the clinical management of several complications secondary to SARS-CoV-2. The rationale and mechanism of action has already been proven clinically in other viral infections and has been shown in research studies to be highly effective at decreasing organ damage mediated by inflammation and oxidative stress. This review summarizes the OT studies that illustrate the possible cytoprotective mechanism of action of ozone and its physiological by-products in target organs affected by SARS-CoV-2. (2) Methods: This review encompasses a total of 74 peer-reviewed original articles. It is mainly focused on ozone as a modulator of the NF-κB/Nrf2 pathways and IL-6/IL-1β expression. (3) Results: In experimental models and the few existent clinical studies, homeostasis of the free radical and antioxidant balance by OT was associated with a modulation of NF-κB/Nrf2 balance and IL-6 and IL-1β expression. These molecular mechanisms support the cytoprotective effects of OT against tissue damage present in many inflammatory diseases, including viral infections. (4) Conclusions: The potential cytoprotective role of OT in the management of organ damage induced by COVID-19 merits further research. Controlled clinical trials are needed.

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Section: Ozone Therapy As Redox Modulatormentioning

confidence: 99%

Potential Cytoprotective Activity of Ozone Therapy in SARS-CoV-2/COVID-19

2020

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“…In the guidelines on the practice of O-MAHT, it is often suggested that low ozone concentrations and stoichiometric amounts be used with respect to the blood to be treated for an overall reduction in side effects. 24,25 However, some ozone therapy practitioners have observed the sporadic appearance of perioral paresthesia, feelings of warmth and/or tachycardia, sensations of coolness in the chest area, and fainting during O-MAHT. These side effects may arise from reinfusing the blood-O2-O3 mixture too quickly.…”

Section: Introductionmentioning

confidence: 99%

The speed of reinfusion affects the vascular system during ozone major autohemotherapy

et al. 2017

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Ozone major autohemotherapy (O-MAHT) is a way of ozonetherapy administration consisting of drawing patient's venous blood, mixing with oxygen/ozone, and reinfusing it into the vein. Some ozone therapists reported side effects during the O-MAHT, but the origin has not been described yet. We investigated the effect of blood drawing velocity during O-MAHT to see its effects on the vascular system and symptomatology. We administered O-MAHT to 11 subjects, and we interleaved fast and slow reinfusions. We monitored cerebral macrocirculation with transcranial Doppler (TCD) and tissue microcirculation with near-infrared spectroscopy (NIRS). Annoying symptoms appeared just during the fast reinfusion periods. NIRS and TCD parameters revealed vasoconstriction during fast reinfusion and improved metabolism during slow reinfusion. Overall, our investigation well discriminated fast from slow reinfusion velocity.

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“…[20] Diyabetik ayak ülserinde, 61 olgu üzerinde yapılan çalışmada, etkinliği şöyle açıklanmaktadır: talamus ve kortekse giden stimülan sinyalleri bloke eden endorfin salını-mı, C-nosiseptörlerin oksidatif dejenerasyonuna bağlı daha az uyarılması, desandan antinosiseptif sistemin aktivasyonu, lokalize oksijenizasyon ve analjezi sonucunda laktat oksidasyonu, asidozun nötralizasyonu, kalsiyum geri alınımı, adenozin-trifosfat (ATP) sentezinde artış ve ödem reabsorpsiyonu ile kasta gevşeme ve vazodilatasyon sağlanması. [1] Tetik nokta enjeksiyonlarında, cilt altına 5 µg/mL ve 2-3 mL, lezyon içine ise 10 µg/mL ve 2-3 mL ozon gazı enjekte edilebilir. Paravertebral kas içi uygulamalarda ise 10 µg/mL ve 5-10 mL ozon uygulamaları yapılabilir.…”

Section: Kronik (İyileşmeyen) Yaralarda Ozon Tedavisiunclassified

Ozon tedavisi

Kesikburun¹,

Yaşar²

2017

TOTBID

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Ozone in Medicine: The Low-Dose Ozone Concept—Guidelines and Treatment Strategies

Cited by 110 publications

References 10 publications

Potential Cytoprotective Activity of Ozone Therapy in SARS-CoV-2/COVID-19

Potential Cytoprotective Activity of Ozone Therapy in SARS-CoV-2/COVID-19

The speed of reinfusion affects the vascular system during ozone major autohemotherapy

Ozon tedavisi

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