The aim of this present work is to find out a suitable and updated hospital pharmacy management system for Bangladesh. Hospital pharmacy is considered as the heart of any hospital because all the departments like surgery, cardiology, nephrology, medicine, pediatric etc. are linked up with pharmacy section. Although the pharmaceutical sector of Bangladesh is enriched so much and the product is up to the mark but the improper management system in hospital pharmacies make the patient’s burden high. So, development is required in hospital pharmacy to ensure the proper choice, preparation, store, compounding and dispense of medicine as well as medical devices along with counseling for patient’s safety and compliance.Bangladesh Pharmaceutical Journal 20(2): 180-187, 2017
The use of natural polymer as excipients in pharmaceutical sector is expanding day by day. Low cost, safety issues, availability, biodegradable are the main causes that make them differ from other sources. Natural sources have wide range of varieties and characteristics. So they can be used numerously in pharmaceutical products as excipients to serve the desired purposes. The aim of this article is to give an over view of the application of natural polymeric substances that can be used as excipients in pharmaceuticals.
Excipients play important roles in the manufacturing of direct compressible tablet. The physical properties of excipients like flow properties, bulk density, tapped density, compressibility and diameter of particles are the most important studies which should be taken under consideration. Excipients like lactose, ludipress, avicel, povidone, sodium starch glycolate, sodium lauryl sulfate, sodium carboxy methyl cellulose, polyethylene glycol 4000 (PEG 4000) and maize starch are used and found that PEG 4000, avicel PH-101, ludipress and sodium lauryl sulfate showed an angle of repose below 40 0 which indicates good flow properties and others are not. The highest compressibility value is obtained from lactose and compressibility value was lowest for PEG 4000. It was found from the average diameter of excipients that sodium starch glycolate is very fine graded powder because all particles pass through a sieve (100 mesh) and the highest value is obtained from PEG 4000.
Fenofibrate, a water insoluble drug was used to prepare matrix tablet with four different viscosity grades of Hydroxypropyl Methylcellulose (HPMC) which were Methocel K4M CR, Methocel K15M CR, Methocel K100M CR and Methocel K100LV CR. The concentration of those excipients was 5, 10, 20, and 40% (w/w), respectively. The content of drug in a fixed quantity of powder in every formulation was ranged between 96.47 to 104.78 %. The dissolution study was done by using USP dissolution apparatus II. The kinetics of release was analyzed by using zero-order, first order, Korsmeyer-Peppas, Higuchi and Hixon-crowell equations to explain the drug release mechanism from the matrix tablets. In-vitro dissolution profile of matrix tablets were dependent upon the HPMC concentration and dissolution was rapid for tablets containing lower polymer proportion i.e. 5,10, and 20% Percentage (w/w) HPMC than those containing 40% (w/w) HPMC.
Bangladesh Pharmaceutical Journal 23(1): 10-16, 2020
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