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The promise of immunotherapy for cancer therapy has not been fully fulfilled because portions of tumors are immunosuppressive. To tackle this challenge, the initiation of immune system by stimulator of interferon genes (STING) pathway is explored and multifunctional STING‐activating nanoparticles are rationally designed for synergistic antitumor therapy. The STING‐activating nanoparticles have a formulation of Mn3O4@Au‐dsDNA/DOX, where dsDNA is used to activate STING for immunotherapy and doxorubicin (DOX) is chosen as a model drug for chemotherapy. The STING‐mediated immunity is activated, inducing interferon‐β (IFN‐β) production, increasing T cell priming, and enhancing effector T cell infiltration. Combined with chemotherapy, STING‐mediated immunotherapy shows good antitumor efficacy by inhibiting tumor growth and prolonging survival rate in vivo. The promise of cancer immunotherapy can be fulfilled by combining novel antitumor immunity with innovative nanotechnology, and chemotherapy and targeted therapies.

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This paper proposed a novel method to prepare porous calcium silicate hydrate (CSH) based on the calcium oxide/polyethylene glycol (CaO/PEG 2000 ) composites as the calcium materials. The porosity formation mechanism was revealed via X-ray diffraction (XRD), field-emission scanning electron microscopy (FESEM), Brunauer-Emmett-Teller (BET), and Fourier transformed infrared spectroscopy (FT-IR). The reactivity of silica materials (SiO 2 ) enhanced by increasing pH value. Ca 2+ could not sustain release from CaO/PEG 2000 and reacted with SiO 3 2− caused by silica to form CSH until the hydrothermal temperature reached to 170 ∘ C, avoiding the hardly dissolved intermediates formation efficiently. The as-prepared CSH, due to the large specific surface areas, exhibited excellent release capability of Ca 2+ and OH − . This porous CSH has potential application in reducing the negative environmental effects of continual natural phosphate resource depletion.