No abstract

Phase change materials (PCM) have drawn increasing attention for their promising applications in thermal switch, data communication and energy storage. Because of the complexity of the interactions between molecules, it...

The solubilities of benzoic acid and its nitrated derivatives (3-nitrobenzoic acid and 3,5-dinitrobenzoic acid) in seven pure solvents—water, methanol, ethanol, acetonitrile, dichloromethane, toluene, and ethyl acetate—were determined experimentally over a temperature range from 273.15 K to 323.15 K under 101.3 kPa. The solubility of the above substances in these solvents increased with temperature. The solubility values of benzoic acid in these seven solvents follow the following order: ethanol > ethanol > acetonitrile > ethyl acetate > dichloromethane > toluene > water, while the solubility values of its nitrification derivatives in these seven solvents follow the following order: methanol > ethanol > ethyl acetate > acetonitrile > dichloromethane > toluene > water. The solubility of benzoic acid, 3-nitrobenzoic acid, and 3,5-dinitrobenzoic acid were significantly different in the same solvent. The solubilities obtained are very helpful in improving the recrystallization and yields of 3-nitrobenzoic acid and 3,5-dinitrobenzoic acid.

Phototherapy is considered a promising alternative to conventional tumor treatments due to its noninvasive modality and effective therapeutic effect. However, designing a photosensitizer with satisfactory therapeutic effect and high security remains a considerable challenge. Herein, a series of dimeric heptamethine cyanine photosensitizers with an aromatic diphenol linker at the meso position is developed to improve the photothermal conversion efficiency (PCE). Thanks to the extended conjugate system and high steric hindrance, the screened 26NA-NIR and 44BP-NIR exhibit high PCE (≈35%), bright near-infrared (NIR) fluorescence, excellent reactive oxygen species (ROS) generation capability, and improved photostability. Furthermore, their outstanding performance on imaging-guided PDT-PTT synergistic therapy is demonstrated by in vivo and in vitro experiments. In conclusion, this study designs a series of dimeric heptamethine cyanine photosensitizers and presents two compounds for potential clinical applications. The strategy provides a new method to design NIR photosensitizers for imaging-guided cancer treatment.

Three-dimensional anion frameworks loaded with small cationic molecules are often reasonable models for design of switching materials. However, due to limitations of bond length and structural stability, it is difficult...