Traditional chemo‐immunotherapy can elicit T cell immune response by inducing immunogenic cell death (ICD), however, insufficient ICD limits the lasting antitumor immunotherapeutic efficacy. Herein, tadpole–ovoid manganese‐doped hollow mesoporous silica coated gold nanoparticles (Au@HMnMSNs) as biodegradable catalytic cascade nanoreactors are constructed to generate intratumoral high‐toxic hydroxyl radicals combined with DOX and Aspirin (ASA) for enhancing the induction of ICD and maturation of dendritic cells (DCs). The released Mn2+ can catalyze endogenous H2O2 to hydroxyl radicals, while internal gold nanoparticles mimetic glucose oxidase (GOx) converted glucose into H2O2 to accelerate the generation of hydroxyl radicals. On the other hand, tadpole oval‐structured Au@HMnMSNs can avoid the inactivation of gold nanoparticles due to strong protein adsorption. The introduction of ASA is to recruit DCs and cytotoxic T lymphocytes (CTLs) to tumor sites and restrain the intratumoral infiltration of immunosuppressive cells by decreasing the expression of prostaglandin E2 (PGE2). Accordingly, this work presents a novel insight to introduce GOx‐like catalytic cascade ICD nano‐inducer into antitumor immunotherapy for synergistic tumor therapy.
We
reported the synthesis of a tris(triazolylmethyl)amine (TTA)-bridged
organosilane, functioning as Cu(I)-stabilizing ligands, and the installation
of this building block into the backbone of mesoporous organosilica
nanoparticles (TTASi) by a sol–gel way. Upon coordinating with
Cu(I), the mesoporous CuI-TTASi, with a restricted metal
active center inside the pore, functions as a molecular-sieve-typed
nanoreactor to efficiently perform Cu(I)-catalyzed alkyne–azide
cycloaddition (CuAAC) reactions on small-molecule substrates but fails
to work on macromolecules larger than the pore diameter. As a proof
of concept, we witnessed the advantages of selective nanoreactors
in screening protein substrates for small molecules. Also, the robust
CuI-TTASi could be implanted into the body of animal models
including zebrafish and mice as biorthogonal catalysts without apparent
toxicity, extending its utilization in vivo ranging
from fluorescent labeling to in situ drug synthesis.
The integration of metal-ion therapy and hydroxyl radical (˙OH)-mediated chemodynamic therapy (CDT) holds great potential for anticancer treatment with high specificity and efficiency.
The solubilities of benzoic acid and its nitrated derivatives (3-nitrobenzoic acid and 3,5-dinitrobenzoic acid) in seven pure solvents—water, methanol, ethanol, acetonitrile, dichloromethane, toluene, and ethyl acetate—were determined experimentally over a temperature range from 273.15 K to 323.15 K under 101.3 kPa. The solubility of the above substances in these solvents increased with temperature. The solubility values of benzoic acid in these seven solvents follow the following order: ethanol > ethanol > acetonitrile > ethyl acetate > dichloromethane > toluene > water, while the solubility values of its nitrification derivatives in these seven solvents follow the following order: methanol > ethanol > ethyl acetate > acetonitrile > dichloromethane > toluene > water. The solubility of benzoic acid, 3-nitrobenzoic acid, and 3,5-dinitrobenzoic acid were significantly different in the same solvent. The solubilities obtained are very helpful in improving the recrystallization and yields of 3-nitrobenzoic acid and 3,5-dinitrobenzoic acid.
The efficacy of free radical-based therapeutic strategies is severely hindered by nonspecific accumulation, premature release and glutathione (GSH) scavenging effects. Herein, a tumor microenvironment-responsive MPDA/AIPH@Cu-TA@HA (abbreviated as MACTH) nanoplatform was...
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