The Cancer Genome Atlas (TCGA) is a publicly funded project that aims to catalog and discover major cancer-causing genomic alterations with the goal of creating a comprehensive 'atlas' of cancer genomic profiles. The availability of this genome-wide information provides an unprecedented opportunity to expand our knowledge of tumourigenesis. Computational analytics and mining are frequently used as effective tools for exploring this byzantine series of biological and biomedical data. However, some of the more advanced computational tools are often difficult to understand or use, thereby limiting their application by scientists who do not have a strong computational background. Hence, it is of great importance to build user-friendly interfaces that allow both computational scientists and life scientists without a computational background to gain greater biological and medical insights. To that end, this survey was designed to systematically present available Web-based tools and facilitate the use TCGA data for cancer research.

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To prevent Traumatic Brain Injury (TBI) patients from secondary brain injuries, patients' physiological readings are continuously monitored. However, the visualization dashboards of most existing monitoring devices cannot effectively present all physiological information of TBI patients and are also ineffective in facilitating neuro-clinicians for fast and accurate diagnosis. To address these shortcomings, we proposed a new visualization dashboard, namely the Multi-signal Visualization of Physiology (MVP). MVP makes use of multi-signal polygram to collate various physiological signals, and it also utilizes colors and the concept of "safe/danger zones" to assist neuro-clinicians to achieve fast and accurate diagnosis. Moreover, MVP allows neuro-clinicians to review historical physiological statuses of TBI patients, which can guide and optimize clinicians' diagnosis and prognosis decisions. The performance of MVP is tested and justified with an actual Philips monitoring device.

The dynamic topology of a mobile ad hoc network poses a real challenge in the design of hierarchical routing protocol, which combines proactive with reactive routing protocols and takes advantages of both. And as an essential technique of hierarchical routing protocol, clustering of nodes provides an efficient method of establishing a hierarchical structure in mobile ad hoc networks. In this paper, we designed a novel clustering algorithm and a corresponding hierarchical routing protocol for large-scale mobile ad hoc networks. Each cluster is composed of a cluster head, several cluster gateway nodes, several cluster guest nodes, and other cluster members. The proposed routing protocol uses proactive protocol between nodes within individual clusters and reactive protocol between clusters. Simulation results show that the proposed clustering algorithm and hierarchical routing protocol provide superior performance with several advantages over existing clustering algorithm and routing protocol, respectively.

Abstract-Large-scale distributed systems deployed as Cloud datacenters are capable of provisioning service to consumers with diverse business requirements. Providers face pressure to provision uninterrupted reliable services while reducing operational costs due to significant software and hardware failures. A widely adopted means to achieve such a goal is using redundant system components to implement user-transparent failover, yet its effectiveness must be balanced carefully without incurring heavy overhead when deployed -an important practical consideration for complex large-scale systems. Failover techniques developed for Cloud systems often suffer serious limitations, including mandatory restart leading to poor cost-effectiveness, as well as solely focusing on crash failures, omitting other important types, such as timing failures and simultaneous failures. This paper addresses these limitations by presenting a new approach to user-transparent failover for massive-scale systems. The approach uses soft-state inference to achieve rapid failure recovery and avoid unnecessary restart, with minimal system resource overhead. It also copes with different failures, including correlated and simultaneous events. The proposed approach was implemented, deployed and evaluated within Fuxi system, the underlying resource management system used within Alibaba Cloud. Results demonstrate that our approach tolerates complex failure scenarios while incurring at worst 228.5 microsecond instance overhead with 1.71% additional CPU usage.