Oxidative damage is an important contributor to the morphological and the functional changes in the development of osteoporosis. In this reported work, the use of cerium oxide (CeO 2 ) nanoparticles as a potential therapeutic agent for osteoporosis is explored. By using the primary osteoblasts (OBs) exposed to hydrogen peroxide (H 2 O 2 ), it is shown that the CeO 2 nanoparticles relieve the H 2 O 2 -induced oxidative damage. The protective effects of the CeO 2 nanoparticles were because of a reduction in the reactive oxygen species (ROS). The level of the antioxidant enzymes was increased after treatment with the CeO 2 nanoparticles in the OBs exposed to H 2 O 2 . Moreover, the cell apoptosis rate was decreased after treatment with the CeO 2 nanoparticles. The CeO 2 nanoparticles protect the OBs against the H 2 O 2 -induced oxidative damage, suppression of the antioxidant enzymes depletion and cell apoptosis via its ROS scavenging mechanism. The findings suggest that the CeO 2 nanoparticles may have a potentially therapeutic value for the diseases related to the ROS.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.