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Two neutral merocyanine-based near-infrared fluorescent probes were for the first time developed through rational engineering of the classical cationic cyanine scaffold IR-780 for in vivo imaging of amyloid-β plaques. In vivo NIRF imaging revealed that the probe could penetrate the blood-brain barrier and efficiently differentiate the living transgenic and wild-type mice.

The hydroxyl substituent in flavonoid can cause the binding site changing from DS1 to DS2 and restores the ESIPT process of flavonoid, thereby leading to an unique dual-emissive response towards...

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