SummaryTransfer RNA (tRNA) is a central component of protein synthesis and cell signaling network. One salient feature of tRNA is its heavily modified status, which can critically impact its function. Here we show that mammalian ALKBH1 is a tRNA demethylase. It mediates the demethylation of N 1 -methyladenosine (m 1 A) in tRNAs. The ALKBH1-catalyzed demethylation of the target tRNAs results in attenuated translation initiation and their decreased usage in protein synthesis. This process is dynamic and responds to glucose availability to affect translation. Our results uncover reversible methylation of tRNA as a new regulatory mechanism of post-transcriptional gene expression.
In briefReversible tRNA methylation helps translation respond to nutrient availability.
An energy cell for scavenging light and thermal energies is reported. This energy cell, consisting of a carbon nanotube film (CNF) integrated with a lead zirconate titanate cantilever, is capable of converting light and thermal energies into electricity. This device is based on actuation of CNF upon illumination by light and thermal radiation and generates an electric potential of 10 V. Experiments show that 2.1 μW power can be generated at a light intensity of 0.13 W/cm2, sufficient to operate some low-power microsensors and integrated circuits.
A polymer-based micromachined Fabry-Perot interferometer (µFPI) with embedded nanostructures in its cavity, called nanostructured-FPI, is reported. The nanostructures inside the cavity are a layer of Au-coated nanopores. As a refractive-index sensitive optical sensor, it offers the following advantages over a traditional µFPI for label-free biosensing applications, including increased sensing surface area, extended penetration depth of the excitation light and amplified optical transducing signals. For a nanostructured-FPI with nanopore size of 50 nm in diameter and the gap size of FPI cavity of 50 µm, measurements find that it has ~20 times improvement in free spectral range (FSR), ~2 times improvement in finesse and ~4 times improvement in contrast of optical transducing signals over a traditional µFPI even without any device performance optimization. Several chemicals have also been evaluated using this device. Fourier transform has been performed on the measured optical signals to facilitate the analysis of the transducing signals.
All 27 intraoral maxillary defect patients were adequately repaired. After surgery, all patients had a favorable wound healing in their first month of follow-up. The surface changed from the typical fatty yellow to a pale yellow-white color after 3 to 4 days, and all fatty surfaces were covered by newly formed reepithelized mucosa in 3 to 4 weeks. The mouth opening and graft was also satisfactory in 7 patients who received adjuvant radiotherapy for carcinoma. So, we conclude that the use of BFP in intraoral maxillary defects is a clinically effective, convenient, safe, and quick method of repair for small to medium-sized defects.
The results suggest that MIF is likely to be an important player in the pathogenesis of ACC and may promote cancer metastasis, which possibly involves JNK inactivation. Further investigation of MIF-mediated molecular events may provide novel insights into the treatment for ACC.
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