BackgroundLocal recurrence and distant metastasis are the main causes of death in patients with lung cancer. Multiple studies have described the recurrence or metastasis of lung cancer at the genetic level. However, association between the microbiome of lung cancer tissue and recurrence or metastasis remains to be discovered. Here, we aimed to identify the bacterial biomarkers capable of distinguishing patients with lung cancer from recurrence or metastasis, and how it related to the severity of patients with lung cancer.MethodsWe applied microbiome pipeline to bacterial communities of 134 non-recurrence and non-metastasis (non-RM) and 174 recurrence or metastasis (RM) samples downloaded from The Cancer Genome Atlas (TCGA). Co-occurrence network was built to explore the bacterial interactions in lung cancer tissue of RM and non-RM. Finally, the Kaplan–Meier survival analysis was used to evaluate the association between bacterial biomarkers and patient survival.ResultsCompared with non-RM, the bacterial community of RM had lower richness and higher Bray–Curtis dissimilarity index. Interestingly, the co-occurrence network of non-RM was more complex than RM. The top 500 genera in relative abundance obtained an area under the curve (AUC) of 0.72 when discriminating between RM and non-RM. There were significant differences in the relative abundances of Acidovorax, Clostridioides, Succinimonas, and Shewanella, and so on between RM and non-RM. These biomarkers played a role in predicting the survival of lung cancer patients and were significantly associated with lung cancer stage.ConclusionThis study provides the first evidence for the prediction of lung cancer recurrence or metastasis by bacteria in lung cancer tissue. Our results highlights that bacterial biomarkers that distinguish RM and non-RM are also associated with patient survival and disease severity.
Acquired digestive‐respiratory tract fistulas occur with abnormal communication between the respiratory tract and digestive tract caused by a variety of benign or malignant diseases, leading to the alimentary canal contents in the respiratory tract. Although various departments have been actively exploring advanced fistula closure techniques, including surgical methods and multimodal therapy, some of which have gotten good clinical effects, there are few large‐scale evidence‐based medical data to guide clinical diagnosis and treatment. The guidelines update the etiology, classification, pathogenesis, diagnosis, and management of acquired digestive‐respiratory tract fistulas. It has been proved that the implantation of the respiratory and digestive stent is the most important and best treatment for acquired digestive‐respiratory tract fistulas. The guidelines conduct an in‐depth review of the current evidence and introduce in detail the selection of stents, implantation methods, postoperative management and efficacy evaluation.
Colorectal cancer (CRC) refers to cancer that develops from the colon or rectum (parts of the large intestine). Signs and symptoms include blood in the stool, changes in bowel movements, weight loss, and fatigue. Since 1923, when the disease was first named, survival rates have always been unsatisfactory. Despite great advances in molecular biology and traditional treatment methods, many questions remain to be answered regarding cancer occurrenceand the underlyingmechanism. Medical doctors remain stymied regarding tumor recurrence and worsening disease after effective treatment. To better understand the relevant questions, in this study, 20 oncogenes and 20 anti-oncogenes were examined in relation to protein structure, from protein structure analysis and dynamic analysis methods to 3D structure analysis and systematic analysis of the structure‒function relationships of proteins. We hope that these analyses will help promote mechanistic research and the development of new treatments for CRC.
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