Preliminary Exploration of Structure–Function Crosstalk in Colorectal Cancer Research: Protein Structuromics

Abstract

Colorectal cancer (CRC) refers to cancer that develops from the colon or rectum (parts of the large intestine). Signs and symptoms include blood in the stool, changes in bowel movements, weight loss, and fatigue. Since 1923, when the disease was first named, survival rates have always been unsatisfactory. Despite great advances in molecular biology and traditional treatment methods, many questions remain to be answered regarding cancer occurrenceand the underlyingmechanism. Medical doctors remain stymied regarding tumor recurrence and worsening disease after effective treatment. To better understand the relevant questions, in this study, 20 oncogenes and 20 anti-oncogenes were examined in relation to protein structure, from protein structure analysis and dynamic analysis methods to 3D structure analysis and systematic analysis of the structure‒function relationships of proteins. We hope that these analyses will help promote mechanistic research and the development of new treatments for CRC.