VRF increased the risk of incident AD dementia. Treatment of VRF was associated with a reduced risk of incident AD dementia. Although our findings are observational, they suggest active intervention for VRF might reduce progression in MCI to AD dementia.
SA-B could effectively reverse liver fibrosis in chronic hepatitis B. SA-B was better than IFN-gamma in reduction of serum HA content, overall decrease of 4 serum fibrotic markers, and decrease of ultrasound imaging score. Liver fibrosis in chronic hepatitis B with slight liver injury was more suitable to SA-B in anti-fibrotic treatment. SA-B showed no obvious side effects.
Among a number of mRNA modifications, N
6
-methyladenosine (m
6
A) modification is the most common type in eukaryotes and nuclear-replicating viruses. m
6
A has a significant role in numerous cancer types, including leukemia, brain tumors, liver cancer, breast cancer and lung cancer. Although m
6
A methyltransferases are essential during RNA modifications, the biological functions of m
6
A and the underlying mechanisms remain to be fully elucidated, predominantly due to the limited detection methods for m
6
A. In the present review, the currently available m
6
A detection methods and the respective scope of their applications are presented to facilitate the further investigation of the roles of m
6
A in biological process.
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