Clinical observation of salvianolic acid B in treatment of liver fibrosis in chronic hepatitis B

Abstract

SA-B could effectively reverse liver fibrosis in chronic hepatitis B. SA-B was better than IFN-gamma in reduction of serum HA content, overall decrease of 4 serum fibrotic markers, and decrease of ultrasound imaging score. Liver fibrosis in chronic hepatitis B with slight liver injury was more suitable to SA-B in anti-fibrotic treatment. SA-B showed no obvious side effects.

Ginkgo biloba extract reverses CCl4–induced liver fibrosis in rats

“…D-penicillamine, which blocks intra-and interchain crosslinking in the newly formed collagen molecules, was found to be ineffective on preventing the progression of hepatic fibrosis and was associated with a high incidence of serious side effects. Medicinally useful plants have made a significant contribution to current medical practice and traditional Chinese herbs are well known for their cheap prices and negligible side effects [31][32][33][34][35][36][37][38][39][40][41] . GbE is a well-known and inexpensive herb that has been used to improve blood circulation without ill effects for centuries in traditional Chinese medicine.…”

Antiproliferative effect of salvianolic acid A on rat hepatic stellate cells

“…Salvianolic acid B, the major polyphenol of S. miltiorrhiza, has been demonstrated to exert protective effects against oxidative stress in hepatocytes and other cells (Kang et al 2004;Zhou et al 2005;Lin et al 2006b), and antifibrogenic effects in both HSCs (Lin et al 2006b) and patients with chronic hepatitis B (Liu et al 2002). Salvianolic acid A (Sal A, Figure 1) is an important bioactive polyphenol, next to salvianolic acid B in content, from S. miltiorrhiza (Li et al 1984).…”

Anti-pulmonary fibrotic activity of salvianolic acid B was screened by a novel method based on the cyto-biophysical properties

“…As the most bioactive component of salvianolic acid extracted from Danshen, SalB shows higher free radical scavenging activity than vitamin C, and its antioxidant capacity is in agreement with its protective effects against cell injury from oxidative stresses [25]. SalB has been reported to protect against liver fibrosis in animals and patients [26,27], as well as to reduce experimental renal interstitial fibrosis in rats [28]. In this study, the SalB was screened to be strongly antipulmonary fibrotic which might also be due to its antioxidant capacity.…”