Ginkgo biloba extract reverses CCl₄–induced liver fibrosis in rats

Abstract

AIM:To study the reversing effect of Ginkgo biloba extract (GbE) on established liver fibrosis in rats.

Beneficial effects of yam on carbon tetrachloride-induced hepatic fibrosis in rats

“…Based on these experimental results, we chose male rats to investigate CCl 4 ‐induced liver damage. Chronic and repeated low‐dose CCl 4 intoxication to induce liver damage and cirrhosis in rats has been described in previous studies 11, 17. In this study, experimental results indicate that CCl 4 treatment decreased body weight, enlarged livers, and elevated liver enzyme activity, including that of AST, ALT, GGT and LDL, but reduced triglyceride levels that did not return to control levels.…”

“…Numerous Chinese herbal medicines, such as Ginkgo biloba extract and Yi‐gan‐kang, have been tested as treatments for chronic liver disease. Both decreased significantly the severity of hepatic fibrosis induced by CCl 4 in rats 17, 18. The 70 W35 strain of Taiwanese yams has superior antioxidant activity,5 and its extracts modulate chemical‐, ethanol‐ and acetaminophen‐induced acute liver toxicity 4, 19…”

Hepatoprotective effect and its possible mechanism of Coptidis rhizoma aqueous extract on carbon tetrachloride-induced chronic liver hepatotoxicity in rats

“…The following is the same) twice a week for 8 weeks. The dose and duration were adopted from the methods of previous studies (Luo et al, 2004;Chung et al, 2005). CRAE treatment groups were given an intraperitoneal injection of CCl 4 at 1 ml/kg per rat twice a week for 8 weeks, and were given CRAE once per day at the dose of 400, 600 and 800 mg/kg BW during the same period.…”

Preventive and curative effect of Lygodium flexuosum (L.) Sw. on carbon tetrachloride induced hepatic fibrosis in rats

“…During liver injury, these lipocytes gets activated and transform into myofibroblasts cells with high proliferative capacity. Most of the antifibrotic herbal drugs reverses fibrosis by increased removal of deposited collagen, enhanced collagenolytic activity and enhanced apoptosis of hepatic stellate cells (Luo et al, 2004). Our results indicate that treatment with Lygodium flexuosum reduces the effects of ongoing toxic liver injury by promoting extracellular matrix degradation in the fibrotic liver and effectively reverses hepatic fibrosis after the establishment of CCl 4 induced hepatic fibrosis in rats through suppression of HSC activation and increased removal of collagen by enhanced collagenolytic activity.…”

“…Asha). Luo et al, 2004;Shih et al, 2005;Gui et al, 2006). Lygodium flexuosum (L.) Sw. a fern belongs to family Lygodiaceae is used in tribal medicine to cure jaundice.…”